Konbu'acidin A, a new bromopyrrole alkaloid with cdk4 inhibitory activity from Hymeniacidon sponge

被引:53
作者
Kobayashi, J
Suzuki, M
Tsuda, M
机构
[1] Faculty of Pharmaceutical Sciences, Hokkaido University
关键词
D O I
10.1016/S0040-4020(97)10022-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new bromopyrrole alkaloid with a fused-hexacyclic skeleton containing two guanidine units, konbu'acidin A (1), has been isolated from an Okinawan marine sponge Hymeniacidon sp., and the structure was elucidated from spectroscopic, data. Compound 1 exhibited inhibitory activity against cyclin dependent kinase 4 (cdk4). (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:15681 / 15684
页数:4
相关论文
共 15 条
[1]   NEW BROMO-PYRROLE DERIVATIVES FROM SPONGE AGELAS-OROIDES [J].
FORENZA, S ;
MINALE, L ;
RICCIO, R .
JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1971, (18) :1129-&
[2]   REINVESTIGATION INTO STRUCTURE OF OROIDIN, A BROMOPYRROLE DERIVATIVE FROM MARINE SPONGE [J].
GARCIA, EE ;
BENJAMIN, LE ;
FRYER, RI .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1973, (03) :78-79
[3]   STYLOGUANIDINES, NEW CHITINASE INHIBITORS FROM THE MARINE SPONGE STYLOTELLA-AURANTIUM [J].
KATO, T ;
SHIZURI, Y ;
IZUMIDA, H ;
YOKOYAMA, A ;
ENDO, M .
TETRAHEDRON LETTERS, 1995, 36 (12) :2133-2136
[4]   BIOACTIVE BROMOPYRROLE METABOLITES FROM THE CARIBBEAN SPONGE AGELAS-CONIFERA [J].
KEIFER, PA ;
SCHWARTZ, RE ;
KOKER, MES ;
HUGHES, RG ;
RITTSCHOF, D ;
RINEHART, KL .
JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (09) :2965-2975
[5]   PALAUAMINE - A CYTOTOXIC AND IMMUNOSUPPRESSIVE HEXACYCLIC BISGUANIDINE ANTIBIOTIC FROM THE SPONGE STYLOTELLA-AGMINATA [J].
KINNEL, RB ;
GEHRKEN, HP ;
SCHEUER, PJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (08) :3376-3377
[6]   A NOVEL ANTAGONIST OF SEROTONERGIC RECEPTORS, HYMENIDIN, ISOLATED FROM THE OKINAWAN MARINE SPONGE HYMENIACIDON SP [J].
KOBAYASHI, J ;
OHIZUMI, Y ;
NAKAMURA, H ;
HIRATA, Y .
EXPERIENTIA, 1986, 42 (10) :1176-1177
[7]   Hymenamide F, new cyclic heptapeptide from marine sponge Hymeniacidon sp. [J].
Kobayashi, J ;
Nakamura, T ;
Tsuda, M .
TETRAHEDRON, 1996, 52 (18) :6355-6360
[8]   A POTENT ACTOMYOSIN ATPASE ACTIVATOR FROM THE OKINAWAN MARINE SPONGE AGELAS CF NEMOECHINATA [J].
KOBAYASHI, J ;
TSUDA, M ;
OHIZUMI, Y .
EXPERIENTIA, 1991, 47 (03) :301-304
[9]   AGELIFERINS, POTENT ACTOMYOSIN ATPASE ACTIVATORS FROM THE OKINAWAN MARINE SPONGE AGELAS SP [J].
KOBAYASHI, J ;
TSUDA, M ;
MURAYAMA, T ;
NAKAMURA, H ;
OHIZUMI, Y ;
ISHIBASHI, M ;
IWAMURA, M ;
OHTA, T ;
NOZOE, S .
TETRAHEDRON, 1990, 46 (16) :5579-5586
[10]   Jaspiferals A-G, new cytotoxic isomalabaricane-type nortriterpenoids from Okinawan marine sponge Jaspis stellifera [J].
Kobayashi, J ;
Yuasa, K ;
Kobayashi, T ;
Sasaki, T ;
Tsuda, M .
TETRAHEDRON, 1996, 52 (16) :5745-5750