The therapeutic use of quercetin in ophthalmology: recent applications

被引：42
作者：
Zhao, Lianghui [1 ,2 ]
Wang, Hongwei [2 ,3 ]
Du, Xianli [2 ,3 ]
机构：
[1] Weifang Med Univ, Weifang 261021, Shandong, Peoples R China
[2] Shandong First Med Univ, Qingdao Eye Hosp, Qingdao 266071, Shandong, Peoples R China
[3] Shandong First Med Univ & Shandong Acad Med Sci, State Key Lab Cultivat Base, Shandong Prov Key Lab Ophthalmol, Shandong Eye Inst, Qingdao 266071, Shandong, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 137卷
关键词：
Therapeutic quercetin; Ophthalmic diseases; Bioactivity; Anti-oxidant; Anti-inflammatory; EPITHELIAL-MESENCHYMAL TRANSITION; ORBITAL FIBROBLASTS; OXIDATIVE STRESS; ALLERGIC CONJUNCTIVITIS; MACULAR DEGENERATION; INSULIN-RESISTANCE; OCULAR SURFACE; IN-VIVO; CELLS; INHIBITION;
D O I：
10.1016/j.biopha.2021.111371
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Quercetin is a natural flavonol antioxidant found in various plant sources and food samples. It is well known for its notable curative effects on the treatment of ophthalmic diseases due to various biological activities, such as antioxidant, anti-inflammatory, and anti-fibrosis activities. This review will discuss the latest developments in therapeutic quercetin for the treatment of keratoconus, Graves? orbitopathy, ocular surface, cataracts, glaucoma, retinoblastoma, and other retinal diseases.
引用
收藏
页数：7
相关论文
共 116 条
  • [1] Topical Quercetin and Resveratrol Protect the Ocular Surface in Experimental Dry Eye Disease
    Abengozar-Vela, Antonio
    Schaumburg, Chris S.
    Stern, Michael E.
    Calonge, Margarita
    Enriquez-de-Salamanca, Amalia
    Jesus Gonzalez-Garcia, Maria
    [J]. OCULAR IMMUNOLOGY AND INFLAMMATION, 2019, 27 (06) : 1023 - 1032
  • [2] Quercetin and Resveratrol Decrease the Inflammatory and Oxidative Responses in Human Ocular Surface Epithelial Cells
    Abengozar-Vela, Antonio
    Calonge, Margarita
    Stern, Michael E.
    Jesus Gonzalez-Garcia, Maria
    Enriquez-De-Salamanca, Amalia
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2015, 56 (04) : 2709 - 2719
  • [3] Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models
    Abokyi, Samuel
    To, Chi-Ho
    Lam, Tim T.
    Tse, Dennis Y.
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020
  • [4] Treatment of Retinoblastoma in 2015 Agreement and Disagreement
    Abramson, David H.
    Shields, Carol L.
    Munier, Francis L.
    Chantada, Guillermo L.
    [J]. JAMA OPHTHALMOLOGY, 2015, 133 (11) : 1341 - 1347
  • [5] Retinoblastoma update
    Aerts, I.
    Lumbroso-Le Rouic, L.
    Gauthier-Villars, M.
    Brisse, H.
    Doz, F.
    [J]. ARCHIVES DE PEDIATRIE, 2016, 23 (01): : 112 - 116
  • [6] Recent developments in age-related macular degeneration: a review
    Al-Zamil, Waseem M.
    Yassin, Sanaa A.
    [J]. CLINICAL INTERVENTIONS IN AGING, 2017, 12 : 1313 - 1330
  • [7] Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)
    Alía, M
    Mateos, R
    Ramos, S
    Lecumberri, E
    Bravo, L
    Goya, L
    [J]. EUROPEAN JOURNAL OF NUTRITION, 2006, 45 (01) : 19 - 28
  • [8] Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model
    Arikan, Sedat
    Ersan, Ismail
    Karaca, Turan
    Kara, Selcuk
    Gencer, Baran
    Karaboga, Ihsan
    Tufan, Hasan Ali
    [J]. ARQUIVOS BRASILEIROS DE OFTALMOLOGIA, 2015, 78 (02) : 100 - 104
  • [9] Armstrong Richard A, 2015, J Stem Cells, V10, P171
  • [10] MECHANISMS OF DISEASE Graves' Ophthalmopathy
    Bahn, Rebecca S.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (08) : 726 - 738
12345678910