2-((4-Phenyl-5-(2-(p-tolylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)-N′-(1-phenylethylidene)acetohydrazide

被引：2

作者：

Sermuksnyte, Aida ^{[1
]}

Jonuskiene, Ilona ^{[1
]}

Kantminiene, Kristina ^{[2
]}

Beresnevicius, Zigmuntas Jonas ^{[1
]}

Tumosiene, Ingrida ^{[1
]}

机构：

[1] Kaunas Univ Technol, Dept Organ Chem, Radvilenu Pl 19, LT-50254 Kaunas, Lithuania

[2] Kaunas Univ Technol, Dept Phys & Inorgan Chem, Radvilenu Pl 19, LT-50254 Kaunas, Lithuania

来源：

MOLBANK | 2022年 / 2022卷 / 02期

关键词：

1,2,4-triazole; hydrazone; Schiff base; antioxidative; ferric reducing antioxidant power (FRAP) assay; BIOLOGICAL EVALUATION; ANTIOXIDANT;

D O I：

10.3390/M1380

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of 2-((4-phenyl-5-(2-(p-tolylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(1-phenylethylidene)acetohydrazide from 2-[(3-{2-[(4-methylphenyl)amino]ethyl}-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-yl)sulfanyl]acetohydrazide and acetophenone is reported. The title compound has been tested to possess 1.5-fold higher antioxidant ability than the control, butylated hydroxytoluene, as determined by a Ferric reducing antioxidant power assay.

引用

页数：5

共 50 条

[1] Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridines as potential antitumor agents
Qin, Mingze
Zhai, Xin
Xie, Hongbo
Ma, Junjie
Lu, Kuan
Wang, Yu
Wang, Lihui
Gu, Yucheng
Gong, Ping
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 81 : 47 - 58
[2] Synthesis and Antimicrobial Activity of 2-[4-(Substituted Benzylidenamino)-5-(Substituted Phenoxymethyl)-4H-1,2,4-Triazol-3-yl thio] Acetic Acid Derivatives
Hunashal, R. D.
Satyanarayana, D.
Maddi, V. S.
E-JOURNAL OF CHEMISTRY, 2012, 9 (03) : 1206 - 1212
[3] Synthesis, anti-inflammatory and analgesic activity of 2-[4-(substituted benzylideneamino)-5-(substituted phenoxymethyl)-4H-1,2,4-triazol-3-yl thio] acetic acid derivatives
Hunashal, R. D.
Ronad, P. M.
Maddi, V. S.
Satyanarayana, D.
Kamadod, M. A.
ARABIAN JOURNAL OF CHEMISTRY, 2014, 7 (06) : 1070 - 1078
[4] SYNTHESIS AND ANTIMICROBIAL ACTIVITY SCREENING OF 2-[4-(SUBSTITUTED BENZYLIDENAMINO)-5-(NAPHTHALEN-4-YLOXY) METHYL-4H-1,2,4-TRIAZOL-3-YL THIO] ACETIC ACID AND 2-[4-(2-SUBSTITUTED BENZYLIDENAMINO)-5-(NAPHTHALEN-4-YLOXY) METHYL-4H-1,2,4-TRIAZOL-3-YL] ISONICOTINYL HYDRAZIDE DERIVATIVES
Hunashal, Rajesh D.
Kumar, M. R. Pradeep
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 27 (02) : 165 - 172
[5] Synthesis and Spectral Characterization of New 2-(5-Aryl-4H-1,2,4-triazol-3-yl)-1H-isoindole-1,3(2H)-dione Derivatives
Alimi, Z.
Hatamjafari, F.
Shiroudi, A.
Pourshamsian, K.
Oliaey, A. R.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 57 (04) : 631 - 637
[6] N′-(4-Chlorobenzylidene)-2-[4-(methylsulfanyl)phenyl]acetohydrazide
Fun, Hoong-Kun
Hemamalini, Madhukar
Sumangala, V.
Prasad, D. Jagadeesh
Poojary, Boja
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2847 - +
[7] Synthesis and Pharmacological Activities of Some New 2-[1-Heptyl-3-(4-methoxybenzyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]acetohydrazide Derivatives
Bekircan, Olcay
Mentese, Emre
Ulkerc, Serdar
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2014, 69 (9-10): : 969 - 981
[8] Microwave-assisted synthesis and antibacterial activity of methyl 1-{2-[4-amino-5-(naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio]ethyl}-1H-indole-3-carboxylate derivatives
Peng, Yongle
Liu, Xingli
Gu, Jian
Zhao, Zhigang
JOURNAL OF CHEMICAL RESEARCH, 2013, (07) : 413 - 416
[9] Synthesis, characterization, and screening for the antimicrobial activity of 2-(3-(2-cyano-2-(p-tolylamino)vinyl)-1H-indol-1-yl)-N-arylacetamide derivatives
Savaniya, Nikhil P.
Khakhariya, Amit D.
Pankhaniya, Priyanka P.
Ladva, Kartik D.
INDIAN JOURNAL OF CHEMISTRY, 2024, 63 (07): : 673 - 677
[10] Synthesis, Characterization and Crystal Structure of Samarium(III)-(E)-1-phenyl-N-(4H-1,2,4-triazol-4-yl)methanimine Complex
Abu-Yamin, Abdel-Aziz
JORDAN JOURNAL OF CHEMISTRY, 2021, 16 (02) : 87 - 94

← 1 2 3 4 5 →