A three-component iodine-catalyzed oxidative coupling reaction: a heterodifunctionalization of 3-methylindoles

被引：3
作者：
Zhang, Wei [1 ,2 ]
Xiang, Shiqun [2 ]
Fan, Weibin [2 ]
Jin, Jiang [2 ]
Li, Yinghua [2 ]
Huang, Deguang [1 ,2 ]
机构：
[1] Fujian Normal Univ, Coll Chem & Mat Sci, Fuzhou 350007, Peoples R China
[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 26期
基金：
中国国家自然科学基金;
关键词：
C-H FUNCTIONALIZATION; ELECTRON-RICH HETEROCYCLES; FRIEDEL-CRAFTS ALKYLATION; METAL-FREE SULFENYLATION; 3-SUBSTITUTED INDOLES; 2,3-DISUBSTITUTED INDOLES; CONTROLLABLE SYNTHESIS; PHOTOREDOX CATALYSIS; CARBONYL-COMPOUNDS; ALPHA;
D O I：
10.1039/d1ob00730k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free method for the synthesis of heterodifunctional indole derivatives is developed through TBHP/KI-mediated oxidative coupling. The reaction constructs C-O and C-C bonds in succession with the help of tert-butyl peroxy radicals generated by the TBHP/KI catalytic system, enabling the direct realization of the heterodifunctionalization of indole in one pot. The product of this reaction is a novel heterodifunctional compound. This work might provide a new effective method for the synthesis of polycyclic indole compounds.
引用
收藏
页码：5794 / 5799
页数：6
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