Megakaryocytes in the hematopoietic stem cell niche

被引：11

作者：

Day, Ryan B. ^{[1
]}

Link, Daniel C. ^{[1
]}

机构：

[1] Washington Univ, Dept Med, St Louis, MO 63130 USA

来源：

NATURE MEDICINE | 2014年 / 20卷 / 11期

关键词：

BONE-MARROW NICHE; MAINTENANCE; QUIESCENCE;

D O I：

10.1038/nm.3745

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesenchymal stromal cells are key components of hematopoietic stem cell (HSC) niches in the bone marrow. Two studies now show that hematopoietic-derived megakaryocytes also contribute to the HSC niche, regulating HSC quiescence and function.

引用

页码：1233 / 1234

页数：2

共 11 条

[1] Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J].

Arai, F ;

Hirao, A ;

Ohmura, M ;

Sato, H ;

Matsuoka, S ;

Takubo, K ;

Ito, K ;

Koh, GY ;

Suda, T .

CELL, 2004, 118 (02) :149-161

[2] Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion [J].

Bruns, Ingmar ;

Lucas, Daniel ;

Pinho, Sandra ;

Ahmed, Jalal ;

Lambert, Michele P. ;

Kunisaki, Yuya ;

Scheiermann, Christoph ;

Schiff, Lauren ;

Poncz, Mortimer ;

Bergman, Aviv ;

Frenette, Paul S. .

NATURE MEDICINE, 2014, 20 (11) :1315-1320

[3] Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches [J].

Ding, Lei ;

Morrison, Sean J. .

NATURE, 2013, 495 (7440) :231-235

[4] CXCL12 in early mesenchymal progenitors is. required for haematopoietic stem-cell maintenance [J].

Greenbaum, Adam ;

Hsu, Yen-Michael S. ;

Day, Ryan B. ;

Schuettpelz, Laura G. ;

Christopher, Matthew J. ;

Borgerding, Joshua N. ;

Nagasawa, Takashi ;

Link, Daniel C. .

NATURE, 2013, 495 (7440) :227-230

[5] Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation [J].

Heazlewood, Shen Y. ;

Neaves, Rebecca J. ;

Williams, Brenda ;

Haylock, David N. ;

Adams, Timothy E. ;

Nilsson, Susan K. .

STEM CELL RESEARCH, 2013, 11 (02) :782-792

[6] Arteriolar niches maintain haematopoietic stem cell quiescence [J].

Kunisaki, Yuya ;

Bruns, Ingmar ;

Scheiermann, Christoph ;

Ahmed, Jalal ;

Pinho, Sandra ;

Zhang, Dachuan ;

Mizoguchi, Toshihide ;

Wei, Qiaozhi ;

Lucas, Daniel ;

Ito, Keisuke ;

Mar, Jessica C. ;

Bergman, Aviv ;

Frenette, Paul S. .

NATURE, 2013, 502 (7473) :637-+

[7] Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment [J].

Nombela-Arrieta, Cesar ;

Pivarnik, Gregory ;

Winkel, Beatrice ;

Canty, Kimberly J. ;

Harley, Brendan ;

Mahoney, John E. ;

Park, Shin-Young ;

Lu, Jiayun ;

Protopopov, Alexei ;

Silberstein, Leslie E. .

NATURE CELL BIOLOGY, 2013, 15 (05) :533-+

[8] Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning [J].

Olson, Timothy S. ;

Caselli, Anna ;

Otsuru, Satoru ;

Hofmann, Ted J. ;

Williams, Richard ;

Paolucci, Paolo ;

Dominici, Massimo ;

Horwitz, Edwin M. .

BLOOD, 2013, 121 (26) :5238-5249

[9]

Thoren L. A., J Immunol, V180, P2045

[10] Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche [J].

Yamazaki, Satoshi ;

Ema, Hideo ;

Karlsson, Goran ;

Yamaguchi, Tomoyuki ;

Miyoshi, Hiroyuki ;

Shioda, Seiji ;

Taketo, Makoto M. ;

Karlsson, Stefan ;

Iwama, Atsushi ;

Nakauchi, Hiromitsu .

CELL, 2011, 147 (05) :1146-1158

← 1 2 →