A synthetic retinoid Am80 (tamibarotene) rescues the memory deficit caused by scopolamine in a passive avoidance paradigm

被引：27
作者：
Shudo, K
Kagechika, H
Yamazaki, N
Igarashi, M
Tateda, C
机构：
[1] Res Fdn, Itsu Lab, Setagaya Ku, Tokyo 1580094, Japan
[2] New Drug Dev Res Ctr, Eniwa, Hokkaido 0611405, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2004年 / 27卷 / 11期
关键词：
retinoid; Alzheimer's disease; tamibarotene; dementia; RAR-ligand;
D O I：
10.1248/bpb.27.1887
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurological disorders.
引用
收藏
页码：1887 / 1889
页数：3
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