Effects of air pollution on mortality of patients with chronic kidney disease: A large observational cohort study

被引：35

作者：

Jung, Jiyun ^{[1
]}

Park, Jae Yoon ^{[2
,3
]}

Kim, Yong Chul ^{[4
]}

Lee, Hyewon ^{[5
,6
]}

Kim, Ejin ^{[7
]}

Kim, Yon Su ^{[4
]}

Lee, Jung Pyo ^{[4
,8
]}

Kim, Ho ^{[7
,9
]}

机构：

[1] Dongguk Univ, Ilsan Hosp, Data Management & Stat Inst, Seoul, South Korea

[2] Dongguk Univ, Ilsan Hosp, Dept Internal Med, Seoul, South Korea

[3] Dongguk Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[4] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea

[5] Soonchunhyang Univ, Coll Med Sci, Dept Hlth Adm & Management, Asan, South Korea

[6] Soonchunhyang Univ, Grad Sch, Dept Software Convergence, Asan, South Korea

[7] Seoul Natl Univ, Inst Hlth & Environm, Seoul, South Korea

[8] Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, 20 Boramae Ro 5 Gil, Seoul 156707, South Korea

[9] Seoul Natl Univ, Sch Publ Hlth, Dept Publ Hlth Sci, Seoul, South Korea

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2021年 / 786卷

基金：

新加坡国家研究基金会;

关键词：

Chronic kidney disease; Air pollution; Long-term exposure; Mortality; SOURCE APPORTIONMENT; PARTICULATE MATTER; EXPOSURE; PM2.5; RISK;

D O I：

10.1016/j.scitotenv.2021.147471

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Due to industrialization, the burden of diseases associated with air pollution is increasing. Although the risk associated with air pollution in the general population has been actively investigated, few studies have been conducted on the effects of exposure to air pollution in patients with chronic kidney disease (CKD) in East Asia. A total of 29,602 patients with CKD in Seoul participated in a retrospective cohort at three medical centers. We assessed the association of individualized exposure to five types of air pollutants (PM2.5, PM10, NO2, SO2, and CO) using inverse distance weighting (IDW) on mortality in CKD patients in the Cox proportional hazard model that was adjusted for sex, age, eGFR, hemoglobin, hypertension, diabetes, and area-level characteristics. During the 6.14 +/- 3.96 years, 3863 deaths (13%) were observed. We confirmed the significant effects of PM2.5 (hazard ratio [HR] 1.17, 95% confidence interval [CI] 1.07-029) and CO (HR 1.17.95% CI 1.00-1.38) on mortality in CKD patients. Different associations were found when stratified by age, body mass index, smoking, and drinking status. Long-term exposure to air pollutants had negative effects on mortality in patients with CKD. These effects were prominent in patients aged over 65 years, patients with a lean body, and those who did not drink alcohol. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：6

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