Effect of 1,25-dihydroxy vitamin D3 on toll-like receptor gene expression in neutrophils of pulmonary tuberculosis

被引：0

作者：

Harishankar, M. ^{[1
]}

Afsal, K. ^{[1
]}

Meenakshi, N. ^{[2
]}

Selvaraj, P. ^{[1
]}

机构：

[1] Indian Council Med Res, Natl Inst Res TB, Dept Immunol, TB Res Ctr, Madras 600031, Tamil Nadu, India

[2] Inst Thorac Med, Madras 600031, Tamil Nadu, India

来源：

CURRENT SCIENCE | 2014年 / 107卷 / 04期

关键词：

Gene expression; neutrophils; tuberculosis; toll-like receptors; MYCOBACTERIUM-TUBERCULOSIS; AUTOPHAGY; ACTIVATION; TLR2;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We studied the effect of 1,25-dihydroxy vitamin D-3 [1,25(OH)(2)D-3] on toll-like receptor (TLR) gene expression in neutrophils cultured with Mycobacterium tuberculosis (Mtb) with or without 1,25(OH)(2)D-3 in pulmonary tuberculosis patients and healthy controls. 1,25(OH)(2)D-3 significantly increased the expression of TLR2, TLR9 and TIRAP genes compared to control cells in both the study groups (P < 0.05). In healthy controls, a significantly upregulated expression of TIRAP was observed in Mtb infected cells cultured with 1,25(OH)(2)D-3 compared to Mtb infected cells alone (P < 0.05). In conclusion, 1,25(OH)(2)D-3 upregulated the expression of TLR and TIRAP genes, which could lead to the activation of TLR signalling pathways and augment the innate immunity to tuberculosis.

引用

页码：642 / 645

页数：4

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