Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction

被引：16

作者：

Sa, Marcus Mandolesi ^{[1
]}

Ferreira, Misael ^{[1
]}

Lima, Emerson Silva ^{[2
]}

Dos Santos, Ivanildes ^{[3
]}

Orlandi, Patrcia Puccinelli ^{[3
]}

Fernandes, Luciano ^{[4
]}

机构：

[1] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Amazonas, Fac Ciencias Farmaceut, Manaus, Amazonas, Brazil

[3] Fundacao Oswaldo Cruz, Ctr Pesquisa Leonidas & Maria Deane, Coordenacao Biodiversidade Saude, Manaus, Amazonas, Brazil

[4] Univ Tecnol Fed Parana, Dept Engn Quim, Ponta Grossa, PR, Brazil

来源：

BRAZILIAN JOURNAL OF MICROBIOLOGY | 2014年 / 45卷 / 03期

关键词：

antimicrobial; allylic thiocyanate; Morita-Baylis-Hillman reaction; MRSA; BIOLOGICAL EVALUATION; ASSISTED SYNTHESIS; TRYPANOSOMA-CRUZI; AQUEOUS-MEDIUM; DERIVATIVES; INHIBITORS; AGENTS; ANTIBIOTICS; RESISTANCE; CHEMISTRY;

D O I：

10.1590/S1517-83822014000300007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.

引用

页码：807 / 812

页数：6

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