Adenylate cyclase toxin from Bordetella pertussis:: current concepts and problems in the study of toxin functions

被引：0
|
作者：
Hewlett, EL
Kim, KJ
Lee, SJ
Gray, MC
机构：
[1] Univ Virginia, Hlth Sci Ctr, Dept Med, Sch Med, Charlottesville, VA 22908 USA
[2] Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22908 USA
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2000年 / 290卷 / 4-5期
关键词：
adenylate cyclase toxin; Bordetella pertussis; acylation; intoxication; K+ efflux; hemolysis;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Adenylate cyclase (AC) toxin produced by Bordella pertussis and other Bordella species is a virulence factor and protective antigen with novel properties and activities, which make it attractive as a prototype toxin for study of membrane insertion and delivery to the target cell interior. It is unique among RTX toxins in that it possesses enzymatic (adenylate cyclase) activity, as well as the capacity to create an ion-permeable pore in target cell membranes and lyse erythrocytes. The current issues in understanding AC toxin, which will be discussed here, include the role of acylation in its various activities and the relationship among those several toxin functions.
引用
收藏
页码：333 / 335
页数：3
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