Bacterial 'competence' genes: signatures of active transformation, or only remnants?

被引：81

作者：

Claverys, JP ^{[1
]}

Martin, B ^{[1
]}

机构：

[1] Univ Toulouse 3, CNRS, UMR 5100, Lab Microbiol & Genet Mol, F-31062 Toulouse, France

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0966-842X(03)00064-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An exhaustive review published ten years ago reported natural genetic transformation, a potential mechanism for intra- and interspecies gene transfer, in similar to40 species belonging to different taxonomic and trophic groups. Since then, considerable progress has been made in characterizing DNA-uptake machineries and regulatory circuits controlling their expression in cells competent for genetic transformation. In this article, in light of the recent description of a Group A streptococcal isolate capable of DNA transfer in mixed cultures, we discuss whether the detection in completely sequenced microbial genomes of intact homologues of key competence-regulatory and/or DNA-uptake proteins enables the prediction of new transformable species.

引用

页码：161 / 165

页数：5

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