Functional role of uterine natural killer (uNK) cells in human early pregnancy decidua

被引：171

作者：

Lash, G. E. ^{[1
]}

Robson, S. C. ^{[1
]}

Bulmer, J. N. ^{[1
]}

机构：

[1] Univ Newcastle, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

PLACENTA | 2010年 / 31卷

关键词：

Uterine natural killer cells; Trophoblast invasion; Spiral artery remodeling; Decidua; Human; ENDOMETRIAL GRANULATED LYMPHOCYTES; MESSENGER RIBONUCLEIC-ACIDS; ENDOTHELIAL GROWTH-FACTOR; FETAL-MATERNAL INTERFACE; NK CELLS; TROPHOBLAST INVASION; SPIRAL ARTERIES; PLACENTAL BED; IFN-GAMMA; IN-VITRO;

D O I：

10.1016/j.placenta.2009.12.022

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leukocytes comprise approximately 30-40% of decidual stromal cells in early human pregnancy. The major leukocyte component is the uterine natural killer (uNK) cells. Despite over 20 years of research the functional role of these cells in situ remains unknown although they have been proposed to play roles in immunotolerance, regulation of trophoblast invasion and remodeling of the spiral arteries. Herein we review the functional roles of this important decidual cell type. (C) 2010 Published by IFPA and Elsevier Ltd.

引用

页码：S87 / S92

页数：6

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