Misfolded proteins, endoplasmic reticulum stress and neurodegeneration

被引：357

作者：

Rao, RV ^{[1
]}

Bredesen, DE ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2004.09.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The accumulation of misfolded proteins (e.g. mutant or damaged proteins) triggers cellular stress responses that protect cells against the toxic buildup of such proteins. However, prolonged stress due to the buildup of these toxic proteins induces specific death pathways. Dissecting these pathways should be valuable in understanding the pathogenesis of, and ultimately in designing therapy for, neurodegenerative diseases that feature misfolded proteins.

引用

收藏

页码：653 / 662

页数：10

相关论文

共 145 条

[1] Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event [J].

Annis, MG ;

Zamzami, N ;

Zhu, WJ ;

Penn, LZ ;

Kroemer, G ;

Leber, B ;

Andrews, DW .

ONCOGENE, 2001, 20 (16) :1939-1952

[2] Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease [J].

Auluck, PK ;

Chan, HYE ;

Trojanowski, JQ ;

Lee, VMY ;

Bonini, NM .

SCIENCE, 2002, 295 (5556) :865-868

[3] Impairment of the ubiquitin-proteasome system by protein aggregation [J].

Bence, NF ;

Sampat, RM ;

Kopito, RR .

SCIENCE, 2001, 292 (5521) :1552-1555

[4] Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response [J].

Bertolotti, A ;

Zhang, YH ;

Hendershot, LM ;

Harding, HP ;

Ron, D .

NATURE CELL BIOLOGY, 2000, 2 (06) :326-332

[5] Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane [J].

Bourdon, JC ;

Renzing, J ;

Robertson, PL ;

Fernandes, KN ;

Lane, DP .

JOURNAL OF CELL BIOLOGY, 2002, 158 (02) :235-246

[6] Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol [J].

Breckenridge, DG ;

Stojanovic, M ;

Marcellus, RC ;

Shore, GC .

JOURNAL OF CELL BIOLOGY, 2003, 160 (07) :1115-1127

[7] The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum [J].

Breckenridge, DG ;

Nguyen, M ;

Kuppig, S ;

Reth, M ;

Shore, GC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (07) :4331-4336

[8] Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis [J].

Bruening, W ;

Roy, J ;

Giasson, B ;

Figlewicz, DA ;

Mushynski, WE ;

Durham, HD .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (02) :693-699

[9] IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA [J].

Calfon, M ;

Zeng, HQ ;

Urano, F ;

Till, JH ;

Hubbard, SR ;

Harding, HP ;

Clark, SG ;

Ron, D .

NATURE, 2002, 415 (6867) :92-96

[10] Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12 [J].

Chan, SL ;

Culmsee, C ;

Haughey, N ;

Klapper, W ;

Mattson, MP .

NEUROBIOLOGY OF DISEASE, 2002, 11 (01) :2-19

← 1 2 3 4 5 6 7 8 9 10 →