On the synthesis of pyrrolobenzo[b]thieno[1,4]diazepines

被引：6
作者：
El-Kashef, Hussein [1 ]
Rathelot, Pascal
Vanelle, Patrice
Rault, Sylvain
机构：
[1] Assiut Univ, Dept Chem, Fac Sci, Assiut, Egypt
[2] Univ Aix Marseille 2, LCOP, UMR CNRS 6517, Fac Pharm, Marseille, France
[3] Univ Caen Basse Normandie, UPRES EA 2126, Ctr Etudes & Rech Medicament Normandie, UFR Sci Pharmaceut, Caen, France
来源：
MONATSHEFTE FUR CHEMIE | 2007年 / 138卷 / 05期
关键词：
1,4]diazepines; thieno[1,4]diazepines; tetrahydrobenzothieno[1,4]diazepines; pyrrolobenzothienodiazepines;
D O I：
10.1007/s00706-007-0591-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile was converted into the corresponding 2-(pyrrol-1-yl) derivative, followed by reduction of the latter compound into the corresponding amine. This amine and its acyl, aroyl, and arylidene derivatives were used as synthons in the synthesis of several title compounds.
引用
收藏
页码：469 / 476
页数：8
相关论文
共 26 条
  • [1] BOULOUARD M, 1995, HETEROCYCLES, V41, P515
  • [2] Pyrrolothieno[1,4]diazepines .4. First synthesis of pyrrolo[1,2-a]thieno[2,3-f][1,4]diazepine derivatives
    Boulouard, M
    Dallemagne, P
    Alsaidi, A
    Rault, S
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, 33 (06) : 1743 - 1749
  • [3] Pyrrolothieno[1,4]diazepines .5. Study of their chemical reactivity and first synthesis of oxazino[4,3-c]pyrrolo[1,2-a]thieno[2,3-f][1,4]diazepines
    Boulouard, M
    Dallemagne, P
    Rault, S
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1997, 34 (04) : 1219 - 1225
  • [4] Pyrrolothieno[1,4]diazepines .3. Synthesis of amino, hydrazino and mercapto derivatives
    Boulouard, M
    Rault, S
    Dallemagne, P
    Alsaidi, A
    Robba, M
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, 33 (01) : 87 - 91
  • [5] RESEARCH ON NITROGEN AND SULFUR HETEROCYCLIC-COMPOUNDS - SYNTHESIS OF 10H-PYRROLO[1,2-A]THIENO[3,4-E][1,4]-DIAZEPIN-5(4H)-ONE AND SOME DERIVATIVES
    DAICH, A
    MOREL, J
    DECROIX, B
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1994, 31 (02) : 341 - 344
  • [6] Synthesis of a new pyrrolo[1,3]diazepine: 4H-pyrrolo[1,2-a]thieno[2,3-e][1,3]diazepine
    Daich, A
    Ohier, P
    Decroix, B
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 32 (06) : 1731 - 1734
  • [7] A NOVEL PRACTICAL SYNTHESIS OF PYRROLO[1,2-A]THIENO[2,3-E][1,4]DIAZEPINES
    DAICH, A
    MOREL, J
    DECROIX, B
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1993, 30 (03) : 675 - 678
  • [8] ORIGINAL AND QUICK ACCESS TO 4-PHENYL-6H-PYRROLO[1,2-ALPHA]THIENO [3,2-F][1,4]DIAZEPINES
    FOLOPPE, MP
    SONNET, P
    RAULT, S
    ROBBA, M
    [J]. TETRAHEDRON LETTERS, 1995, 36 (18) : 3127 - 3128
  • [9] New access to 4-phenyl-6H-pyrrolo[1,2-a]thieno[3,2-f][1,4]diazepines
    Foloppe, MP
    Sonnet, P
    Bureau, I
    Rault, S
    Robba, M
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, 33 (01) : 75 - 80
  • [10] FUJIMORI K, 1977, Patent No. 52100496
123