Type I interferon induces cancer stem cells-mediated chemotherapy resistance

被引：11

作者：

De Martino, Mara ^{[1
]}

Vanpouille-Box, Claire ^{[1
,2
]}

机构：

[1] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA

[2] Sandra & Edward Meyer Canc Ctr, New York, NY USA

来源：

ONCOIMMUNOLOGY | 2022年 / 11卷 / 01期

关键词：

Chemotherapy; immunogenic cell death; epigenetic immune escape; cancer stem cells; interferon type I; KDM1B;

D O I：

10.1080/2162402X.2022.2127274

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a recent study in Nature Immunology, Musella et al. demonstrate that suboptimal type I interferon (IFN-I) signaling in tumors undergoing immunogenic cell death (ICD) facilitates the accumulation of cancer stem cells (CSCs) by triggering the epigenetic regulator lysine demethylase 1B (KDM1B). KDM1B stands out as a promising target for the development of novel strategies to improve anti-cancer responses driven by ICD.

引用

页数：3

共 10 条

[1] Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy [J].

Boukhaled, Giselle M. ;

Gadalla, Ramy ;

Elsaesser, Heidi J. ;

Abd-Rabbo, Diala ;

Quevedo, Rene ;

Yang, S. Y. Cindy ;

Guo, Mengdi ;

Wang, Ben X. ;

Noamani, Babak ;

Gray, Diana ;

Lau, Sally C. M. ;

Taylor, Kirsty ;

Aung, Kyaw ;

Spreafico, Anna ;

Hansen, Aaron R. ;

Saibil, Samuel D. ;

Hirano, Naoto ;

Guidos, Cynthia ;

Pugh, Trevor J. ;

McGaha, Tracy L. ;

Ohashi, Pamela S. ;

Sacher, Adrian G. ;

Butler, Marcus O. ;

Brooks, David G. .

NATURE IMMUNOLOGY, 2022, 23 (08) :1273-+

[2] Cancer-specific type-I interferon receptor signaling promotes cancer stemness and effector CD8+T-cell exhaustion [J].

Gong, Wang ;

Donnelly, Christopher R. ;

Heath, Blake R. ;

Bellile, Emily ;

Donnelly, Lorenza A. ;

Taner, Hulya F. ;

Broses, Luke ;

Brenner, J. Chad ;

Chinn, Steven B. ;

Ji, Ru-Rong ;

Wen, Haitao ;

Nor, Jacques E. ;

Wang, Jie ;

Wolf, Gregory T. ;

Xie, Yuying ;

Lei, Yu Leo .

ONCOIMMUNOLOGY, 2021, 10 (01)

[3]

Greiner A. C., 2003, Health professions education: A bridge to quality, DOI [10.17226/10681, DOI 10.17226/10681]

[4] Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B [J].

Musella, Martina ;

Guarracino, Andrea ;

Manduca, Nicoletta ;

Galassi, Claudia ;

Ruggiero, Eliana ;

Potenza, Alessia ;

Maccafeo, Ester ;

Manic, Gwenola ;

Mattiello, Luca ;

Rehim, Sara Soliman Abdel ;

Signore, Michele ;

Pietrosanto, Marco ;

Helmer-Citterich, Manuela ;

Pallocca, Matteo ;

Fanciulli, Maurizio ;

Bruno, Tiziana ;

De Nicola, Francesca ;

Corleone, Giacomo ;

Di Benedetto, Anna ;

Ercolani, Cristiana ;

Pescarmona, Edoardo ;

Pizzuti, Laura ;

Guidi, Francesco ;

Sperati, Francesca ;

Vitale, Sara ;

Macchia, Daniele ;

Spada, Massimo ;

Schiavoni, Giovanna ;

Mattei, Fabrizio ;

De Ninno, Adele ;

Businaro, Luca ;

Lucarini, Valeria ;

Bracci, Laura ;

Arico, Eleonora ;

Ziccheddu, Giovanna ;

Facchiano, Francesco ;

Rossi, Stefania ;

Sanchez, Massimo ;

Boe, Alessandra ;

Biffoni, Mauro ;

De Maria, Ruggero ;

Vitale, Ilio ;

Sistigu, Antonella .

NATURE IMMUNOLOGY, 2022, 23 (09) :1379-+

[5] Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients [J].

Rodriguez-Ruiz, Maria Esperanza ;

Buque, Aitziber ;

Hensler, Michal ;

Chen, Jonathan ;

Bloy, Norma ;

Petroni, Giulia ;

Sato, Ai ;

Yamazaki, Takahiro ;

Fucikova, Jitka ;

Galluzzi, Lorenzo .

ONCOIMMUNOLOGY, 2019, 8 (11)

[6] Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy [J].

Sistigu, Antonella ;

Yamazaki, Takahiro ;

Vacchelli, Erika ;

Chaba, Kariman ;

Enot, David P. ;

Adam, Julien ;

Vitale, Ilio ;

Goubar, Aicha ;

Baracco, Elisa E. ;

Remedios, Catarina ;

Fend, Laetitia ;

Hannani, Dalil ;

Aymeric, Laetitia ;

Ma, Yuting ;

Niso-Santano, Mireia ;

Kepp, Oliver ;

Schultze, Joachim L. ;

Tueting, Thomas ;

Belardelli, Filippo ;

Bracci, Laura ;

La Sorsa, Valentina ;

Ziccheddu, Giovanna ;

Sestili, Paola ;

Urbani, Francesca ;

Delorenzi, Mauro ;

Lacroix-Triki, Magali ;

Quidville, Virginie ;

Conforti, Rosa ;

Spano, Jean-Philippe ;

Pusztai, Lajos ;

Poirier-Colame, Vichnou ;

Delaloge, Suzette ;

Penault-Llorca, Frederique ;

Ladoire, Sylvain ;

Arnould, Laurent ;

Cyrta, Joanna ;

Dessoliers, Marie-Charlotte ;

Eggermont, Alexander ;

Bianchi, Marco E. ;

Pittet, Mikael ;

Engblom, Camilla ;

Pfirschke, Christina ;

Preville, Xavier ;

Uze, Gilles ;

Schreiber, Robert D. ;

Chow, Melvyn T. ;

Smyth, Mark J. ;

Proietti, Enrico ;

Andre, Fabrice ;

Kroemer, Guido .

NATURE MEDICINE, 2014, 20 (11) :1301-1309

[7] Type I interferons and endoplasmic reticulum stress in health and disease [J].

Sprooten, Jenny ;

Garg, Abhishek D. .

BIOLOGY OF THE ENDOPLASMIC RETICULUM, 2020, 350 :63-118

[8] DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity [J].

Vanpouille-Box, Claire ;

Alard, Amandine ;

Aryankalayil, Molykutty J. ;

Sarfraz, Yasmeen ;

Diamond, Julie M. ;

Schneider, Robert J. ;

Inghirami, Giorgio ;

Coleman, C. Norman ;

Formenti, Silvia C. ;

Demaria, Sandra .

NATURE COMMUNICATIONS, 2017, 8 :15618

[9] Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy [J].

Yamazaki, Takahiro ;

Kirchmair, Alexander ;

Sato, Ai ;

Buque, Aitziber ;

Rybstein, Marissa ;

Petroni, Giulia ;

Bloy, Norma ;

Finotello, Francesca ;

Stafford, Lena ;

Navarro Manzano, Esther ;

Ayala de la Pena, Francisco ;

Garcia-Martinez, Elena ;

Formenti, Silvia C. ;

Trajanoski, Zlatko ;

Galluzzi, Lorenzo .

NATURE IMMUNOLOGY, 2020, 21 (10) :1160-+

[10] Double-edged effects of interferons on the regulation of cancer-immunity cycle [J].

Zhang, Xiao ;

Wang, Song ;

Zhu, Yuanyuan ;

Zhang, Minghui ;

Zhao, Yan ;

Yan, Zhengbin ;

Wang, Qiuxu ;

Li, Xiaobo .

ONCOIMMUNOLOGY, 2021, 10 (01)

← 1 →