Coupling crossover and synaptonemal complex in meiosis

被引：14

作者：

Grey, Corinne ^{[1
]}

de Massy, Bernard ^{[1
]}

机构：

[1] Univ Montpellier, Ctr Natl Rech Sci, Inst Genet Humaine IGH, F-34396 Montpellier, France

来源：

GENES & DEVELOPMENT | 2022年 / 36卷 / 1-2期

关键词：

aneuploidy; crossing over; homologous recombination; meiosis; chromosome segregation; DSB repair; protein-protein interactions; homologous synapsis;

D O I：

10.1101/gad.349286.121

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During meiosis, a molecular program induces DNA double-strand breaks (DSBs) and their repair by homologous recombination. DSBs can be repaired with or without crossovers. ZMM proteins promote the repair toward crossover. The sites of DSB repair are also sites where the axes of homologous chromosomes are juxtaposed and stabilized, and where a structure called the synaptonemal complex initiates, providing further regulation of both DSB formation and repair. How crossover formation and synapsis initiation are linked has remained unknown. The study by Pyatnitskaya and colleagues (pp. 53-69) in this issue of Genes & Development highlights the central role of the Saccharomyces cerevisiae ZMM protein Zip4 in this process.

引用

页码：4 / 6

页数：3

共 11 条

[1] The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding [J].

Arora, Kanika ;

Corbett, Kevin D. .

NUCLEIC ACIDS RESEARCH, 2019, 47 (05) :2365-2376

[2] A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation [J].

De Muyt, Arnaud ;

Pyatnitskaya, Alexandra ;

Andreani, Jessica ;

Ranjha, Lepakshi ;

Ramus, Claire ;

Laureau, Raphaelle ;

Fernandez-Vega, Ambra ;

Holoch, Daniel ;

Girard, Elodie ;

Govin, Jerome ;

Margueron, Raphael ;

Coute, Yohann ;

Cejka, Petr ;

Guerois, Raphael ;

Borde, Valerie .

GENES & DEVELOPMENT, 2018, 32 (3-4) :283-296

[3] Building bridges to move recombination complexes [J].

Dubois, Emeline ;

De Muyt, Arnaud ;

Soyer, Jessica L. ;

Budin, Karine ;

Legras, Mathieu ;

Piolot, Tristan ;

Debuchy, Robert ;

Kleckner, Nancy ;

Zickler, Denise ;

Espagne, Eric .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (25) :12400-12409

[4] The Ecm11-Gmc2 Complex Promotes Synaptonemal Complex Formation through Assembly of Transverse Filaments in Budding Yeast [J].

Humphryes, Neil ;

Leung, Wing-Kit ;

Argunhan, Bilge ;

Terentyev, Yaroslav ;

Dvorackova, Martina ;

Tsubouchi, Hideo .

PLOS GENETICS, 2013, 9 (01)

[5] Meiotic Recombination: The Essence of Heredity [J].

Hunter, Neil .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2015, 7 (12)

[6] The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation [J].

Lee, Min-Su ;

Higashide, Mika T. ;

Choi, Hyungseok ;

Li, Ke ;

Hong, Soogil ;

Lee, Kangseok ;

Shinohara, Akira ;

Shinohara, Miki ;

Kim, Keun P. .

NUCLEIC ACIDS RESEARCH, 2021, 49 (13) :7537-7553

[7] The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly [J].

Pyatnitskaya, Alexandra ;

Andreani, Jessica ;

Guerois, Raphael ;

De Muyt, Arnaud ;

Borde, Valerie .

GENES & DEVELOPMENT, 2022, 36 (1-2) :53-69

[8] Crossing and zipping: molecular duties of the ZMM proteins in meiosis [J].

Pyatnitskaya, Alexandra ;

Borde, Valerie ;

De Muyt, Arnaud .

CHROMOSOMA, 2019, 128 (03) :181-198

[9] The meiosis-specific Zip4 protein regulates crossover distribution by promoting synaptonernal complex formation together with Zip2 [J].

Tsubouchi, Tomomi ;

Zhao, Hongyu ;

Roeder, G. Shirleen .

DEVELOPMENTAL CELL, 2006, 10 (06) :809-819

[10] Synaptonemal Complex Proteins of Budding Yeast Define Reciprocal Roles in MutSγ-Mediated Crossover Formation [J].

Voelkel-Meiman, Karen ;

Cheng, Shun-Yun ;

Morehouse, Savannah J. ;

MacQueen, Amy J. .

GENETICS, 2016, 203 (03) :1091-+

← 1 2 →