Synthesis and biological evaluation of 1,2,4,5-tetrasubstituted imidazoles

被引：12

作者：

Fang, Yue ^{[1
]}

Yuan, Rui ^{[1
]}

Ge, Wen-hui ^{[1
]}

Wang, Yuan-jiang ^{[1
]}

Liu, Gui-xiang ^{[1
]}

Li, Ming-qi ^{[1
]}

Xu, Jiang-biao ^{[1
]}

Wan, Yu ^{[2
]}

Zhou, Sheng-liang ^{[2
]}

Han, Xi-guang ^{[1
]}

Zhang, Peng ^{[2
]}

Liu, Jin-juan ^{[2
]}

Wu, Hui ^{[1
,2
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Peoples R China

[2] Jiangsu Normal Univ, State Key Lab Cultivat Construct Base Biotechnol, Xuzhou 221116, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2017年 / 43卷 / 08期

关键词：

Tetrasubstituted imidazoles; Porous CeO2 Nanorod; Synthesis; Bioactivity; ONE-POT SYNTHESIS; SOLVENT-FREE SYNTHESIS; NANO INDIUM OXIDE; TETRASUBSTITUTED IMIDAZOLES; MAGNETIC NANOPARTICLES; HIGHLY-EFFICIENT; CATALYST; 2,4,5-TRIARYL-1H-IMIDAZOLES; DERIVATIVES; 4-COMPONENT;

D O I：

10.1007/s11164-017-2886-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tetrasubstituted imidazoles were synthesized in high yields via the four-component reaction of aromatic aldehydes, amines, substituted benzils and ammonium acetate catalyzed by a porous CeO2 nanorod. Their anti-cancer activities on the Huh-7 hepatocellular carcinoma cell and antibacterial activities on four bacterial species (wild-type Escherichia coli, wild-type Staphylococcus aureus, Pseudomonas aeruginosa PAM1032 and Escherichia coli-NMD-1) in vitro were evaluated. One compound (5p) was screened out because of its high inhibition rate on all four bacterials at 100 mu g/mL. Three products (5p, 5t and 5y) showed a high inhibition rate on the Huh-7 hepatocellular carcinoma cell at 10 mu g/mL. The results indicated their potential in new drug development.

引用

页码：4413 / 4421

页数：9

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