Effects of Poloxamer 188 on red blood cell membrane properties in sickle cell anaemia

被引：22

作者：

Sandor, Barbara ^{[1
]}

Marin, Mickael ^{[2
,3
,4
]}

Lapoumeroulie, Claudine ^{[2
,3
,4
]}

Rabai, Miklos ^{[1
]}

Lefevre, Sophie D. ^{[2
,3
,4
,5
]}

Lemonne, Nathalie ^{[6
]}

El Nemer, Wassim ^{[2
,3
,4
]}

Mozar, Anais ^{[4
,7
]}

Francais, Olivier ^{[8
]}

Le Pioufle, Bruno ^{[8
]}

Connes, Philippe ^{[4
,7
,8
,9
,10
]}

Le van Kim, Caroline ^{[2
,3
,4
,5
]}

机构：

[1] Univ Pecs, Sch Med, Pecs, Hungary

[2] INSERM, UMR S1134, Paris, France

[3] Inst Natl Transfus Sanguine, F-75015 Paris, France

[4] Lab Excellence GR Ex, Paris, France

[5] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France

[6] CHU Pointe A Pitre, Pointe A Pitre, Guadeloupe, France

[7] Univ Antilles Guyane, INSERM, Pointe A Pitre 97159, Guadeloupe, France

[8] Ecole Normale Super, BIOMIS SATIE, CNRS, UMR 8029, Cachan, France

[9] Univ Lyon 1, Sect Vasc Biol & Red Blood Cell, Lab CRIS EA647, F-69365 Lyon, France

[10] Inst Univ France, Paris, France

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2016年 / 173卷 / 01期

关键词：

sickle cell anaemia; poloxamer; red blood cell; AGGREGATION; ENDOTHELIUM; INHIBITION; VISCOSITY; ADHESION;

D O I：

10.1111/bjh.13937

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vaso-occlusive crisis (VOC) is the main acute complication in sickle cell anaemia (SS) and several clinical trials are investigating different drugs to improve the clinical severity of SS patients. A phase III study is currently exploring the profit of Velopoloxamer in SS during VOCs. We analysed, in-vitro, the effect of poloxamer (P188) on red blood cell (RBC) properties by investigating haemorheology, mechanical and adhesion functions using ektacytometry, microfluidics and dynamic adhesion approaches, respectively. We show that poloxamer significantly reduces blood viscosity, RBC aggregation and adhesion to endothelial cells, supporting the beneficial use of this molecule in SS therapy.

引用

页码：145 / 149

页数：5

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