FTIR, Electrochemical Impedance and Iontophoretic Delivery Analysis of Guar Gum and Sesame Oil Based Bigels

被引：2
作者：
Singh, Vinay K. [1 ]
Anis, Arfat [2 ]
Al-Zahrani, S. M. [2 ]
Pradhan, Dillip K. [3 ]
Pal, Kunal [1 ]
机构：
[1] Natl Inst Technol, Dept Biotechnol & Med Engn, Rourkela 769008, Odisha, India
[2] King Saud Univ, Dept Chem Engn, Riyadh 11421, Saudi Arabia
[3] Natl Inst Technol, Dept Phys, Rourkela 769008, Odisha, India
来源：
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | 2014年 / 9卷 / 10期
关键词：
iontophoresis; bigels; guar gum; impedance spectroscopy; DRUG-DELIVERY; SORBITAN MONOPALMITATE; SPECTROSCOPY; ORGANOGELS; CORROSION; BEHAVIOR; RELEASE; SYSTEM;
D O I：
暂无
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
The objective of this study was to investigate the electrochemical properties of the prepared bigels and iontophoretic delivery of metronidazole for topical application. Bigels were prepared by mixing guar gum aquagel and Span 60-sesame oil based oleogel. FTIR spectra showed the formation of intermolecular hydrogen bonding. Impedance spectroscopy confirmed the conductive nature of bigels. The iontophoretic release study of metronidazole loaded bigels showed concentration dependent release of the drugs. The bigel containing higher concentrations of oleogel showed lower amount of drug release and followed zero order release kinetics. In conclusion, the results demonstrate that iontophoresis of metronidazole enables local enhanced topical delivery for treating various diseased conditions.
引用
收藏
页码：5640 / 5650
页数：11
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