Application of comparative genomic hybridization in search for genetic aberrations in fibroadenomas of the breast

被引：13
作者：
Amiel, A [1 ]
Kaufman, Z
Goldstein, E
Bruchim, RBS
Kidron, D
Gaber, E
Fejgin, MD
机构：
[1] Meir Hosp, Inst Genet, IL-44281 Kefar Sava, Israel
[2] Bar Ilan Univ, Fac Life Sci, IL-52100 Ramat Gan, Israel
[3] Meir Hosp, Breast Hlth Unit, IL-44281 Kefar Sava, Israel
[4] Tel Aviv Univ, IL-69978 Tel Aviv, Israel
[5] Meir Hosp, Inst Pathol, IL-44281 Kefar Sava, Israel
来源：
CANCER GENETICS AND CYTOGENETICS | 2003年 / 142卷 / 02期
关键词：
D O I：
10.1016/S0165-4608(02)00833-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We applied a comparative genomic hybridization (CGH) technique to paraffin-embedded tissue samples taken from fibroadenomas, benign breast tumors, to detect possible numerical and unbalanced genetic changes. We compared the results to those from previous cytogenetic studies of fibroadenomas. In concurrence with previous cytogenetic studies of fibroadenomas, we detected genetic aberrations in chromosomes 4-6, 8-13, 16, 18, 19, 20, and 22. In addition, with the CGH technique we were able to find two new aberrations, 15q+ and 16p-. Because these aberrations have also been reported to be present in breast cancer, the importance of this finding is yet to be determined. (C) 2003 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：145 / 148
页数：4
相关论文
共 41 条
  • [1] CGH in the detection of confined placental mosaicism (CPM) in placentas of abnormal pregnancies
    Amiel, A
    Bouaron, N
    Kidron, D
    Sharony, R
    Gaber, E
    Fejgin, MD
    [J]. PRENATAL DIAGNOSIS, 2002, 22 (09) : 752 - 758
  • [2] Aubele M, 2000, INT J CANCER, V85, P82, DOI 10.1002/(SICI)1097-0215(20000101)85:1<82::AID-IJC15>3.0.CO
  • [3] 2-S
  • [4] Heterogeneous chromosomal aberrations in intraductal breast lesions adjacent to invasive carcinoma
    Aubele, M
    Cummings, M
    Walch, A
    Zitzelsberger, H
    Nährig, J
    Höfler, H
    Werner, M
    [J]. ANALYTICAL CELLULAR PATHOLOGY, 2000, 20 (01): : 17 - 24
  • [5] Accumulation of chromosomal imbalances from intraductal proliferative lesions to adjacent in situ and invasive ductal breast cancer
    Aubele, MM
    Cummings, MC
    Mattis, AE
    Zitzelsberger, HF
    Walch, AK
    Kremer, M
    Höfler, H
    Werner, M
    [J]. DIAGNOSTIC MOLECULAR PATHOLOGY, 2000, 9 (01) : 14 - 19
  • [6] Barrett IJ, 2001, ARCH PATHOL LAB MED, V125, P81
  • [7] BENIGN BREAST DISEASES, CARCINOMA IN-SITU, AND BREAST-CANCER RISK
    BODIAN, CA
    [J]. EPIDEMIOLOGIC REVIEWS, 1993, 15 (01) : 177 - 187
  • [8] Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns
    Boecker, W
    Buerger, H
    Schmitz, K
    Ellis, IA
    van Diest, PJ
    Sinn, HP
    Geradts, J
    Diallo, R
    Poremba, C
    Herbst, H
    [J]. JOURNAL OF PATHOLOGY, 2001, 195 (04) : 415 - 421
  • [9] CHROMOSOME-ABNORMALITIES IN BREAST FIBROADENOMAS
    CALABRESE, G
    DIVIRGILIO, C
    CIANCHETTI, E
    FRANCHI, PG
    STUPPIA, L
    PARRUTI, G
    BIANCHI, PG
    PALKA, G
    [J]. GENES CHROMOSOMES & CANCER, 1991, 3 (03) : 202 - 204
  • [10] Clonal chromosomal alterations in fibroadenomas of the breast
    Cavalli, LR
    Cornélio, DA
    Wuicik, L
    Bras, ATS
    Ribeiro, EMSF
    Lima, RS
    Urban, CA
    Rogatto, SR
    Cavalli, IJ
    [J]. CANCER GENETICS AND CYTOGENETICS, 2001, 131 (02) : 120 - 124
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