Small-molecule binding to the nonquadruplex form of the human telomeric sequence

被引：8
作者：
Goto, Yuki [1 ]
Hagihara, Shinya [1 ]
Hagihara, Masaki [1 ]
Nakatani, Kazuhiko [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Synth Chem & Biol Chem, Kyoto 6158510, Japan
来源：
CHEMBIOCHEM | 2007年 / 8卷 / 07期
关键词：
inhibitors; ligand effects; mismatches; telomere repeats;
D O I：
10.1002/cbic.200600564
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(Figure Presented) The single-stranded region of the d-(TTAGGG) repeat is known to form a G-quadruplex structure in vitro. We report here a novel naphthyridine tetramer (NT) ligand that induces a nonquadruplex structure in the single-stranded region of the human telomeric sequence. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：723 / 726
页数：4
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