In vitro activity of eight oral cephalosporins against Borrelia burgdorferi

被引：13
作者：
Hunfeld, KP [1 ]
Rödel, R [1 ]
Wichelhaus, TA [1 ]
机构：
[1] Univ Hosp Frankfurt, Inst Med Microbiol, D-60596 Frankfurt, Germany
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2003年 / 21卷 / 04期
关键词：
Borrelia burgdorferi; cephalosporins; minimal inhibitory concentration; in vitro susceptibility;
D O I：
10.1016/S0924-8579(03)00005-0
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Oral cephalosporins have not previously been extensively tested against larger numbers of Borrelia burgdorferi isolates derived from different clinical and geographical sources. This study investigated the in vitro activity of eight oral cephalosporins in addition to ceftriaxone and apramycin, against 17 isolates of the B. burgdorferi complex, including one B. valaisiana and one B. bissettii tick isolate. Minimal inhibitory concentrations and minimal borreliacidal concentrations providing 100% killing of the final inoculuin were determined by a standardised methodology in Barbour-Stoermer-Kelly-medium after 72 h of incubation. The rank order of potency was ceftriaxone > cefuroxime-axetil > cefixime, cefdinir > cefpodoxime > cefaclor > ceftibuten, loracarbef > cefetametpivoxil, apramycin. Our study demonstrates the superior in vitro effectiveness of ceftriaxone with good to excellent activity with the oral agents cefuroxime-axetil, cefixime and cefdinir against B. burgdorferi under strictly standardised test conditions. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.
引用
收藏
页码：313 / 318
页数：6
相关论文
共 22 条
[1]   INVITRO SUSCEPTIBILITIES OF BORRELIA-BURGDORFERI TO 5 ORAL CEPHALOSPORINS AND CEFTRIAXONE [J].
AGGER, WA ;
CALLISTER, SM ;
JOBE, DA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (08) :1788-1790
[2]   PENICILLINS, CEPHALOSPORINS, AND TETRACYCLINES IN TREATMENT OF HAMSTERS WITH FATAL LEPTOSPIROSIS [J].
ALEXANDER, AD ;
RULE, PL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (06) :835-839
[3]   Penicillin-binding proteins in Leptospira interrogans [J].
Brenot, A ;
Trott, D ;
Saint Girons, I ;
Zuerner, R .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (03) :870-877
[4]   INVITRO ACTIVITY OF VANCOMYCIN AGAINST THE SPIROCHETE BORRELIA-BURGDORFERI [J].
DEVER, LL ;
JORGENSEN, JH ;
BARBOUR, AG .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (05) :1115-1121
[5]  
HANSEN K, 1992, ACTA DERM-VENEREOL, V72, P297
[6]   Standardised in vitro susceptibility testing of Borrelia burgdorferi against well-known and newly developed antimicrobial agents -: Possible implications for new therapeutic approaches to Lyme disease [J].
Hunfeld, KP ;
Kraiczy, P ;
Kekoukh, E ;
Schäfer, V ;
Brade, V .
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2002, 291 :125-137
[7]   In vitro susceptibility of the Borrelia burgdorferi sensu lato complex to ABT-773, a novel ketolide [J].
Hunfeld, KP ;
Wichelhaus, TA ;
Kekoukh, E ;
Molitor, M ;
Kraiczy, P ;
Brade, V .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 (03) :447-449
[8]   In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi [J].
Hunfeld, KP ;
Weigand, J ;
Wichelhaus, TA ;
Kekoukh, E ;
Kraiczy, P ;
Brade, V .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2001, 17 (03) :203-208
[9]   New colorimetric microdilution method for in vitro susceptibility testing of Borrelia burgdorferi against antimicrobial substances [J].
Hunfeld, KP ;
Kraiczy, P ;
Wichelhaus, TA ;
Schäfer, V ;
Brade, V .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2000, 19 (01) :27-32
[10]   Colorimetric in vitro susceptibility testing of penicillins, cephalosporins, macrolides, streptogramins, tetracyclines, and aminoglycosides against Borrelia burgdorferi isolates [J].
Hunfeld, KP ;
Kraiczy, P ;
Wichelhaus, TA ;
Schäfer, V ;
Brade, V .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 15 (01) :11-17
123