The changing therapeutic landscape of head and neck cancer

被引：542

作者：

Cramer, John D. ^{[1
]}

Burtness, Barbara ^{[2
,3
]}

Quynh Thu Le ^{[4
]}

Ferris, Robert L. ^{[5
,6
,7
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Otolaryngol, Detroit, MI 48201 USA

[2] Yale Sch Med, Dept Med, New Haven, CT USA

[3] Yale Sch Med, Yale Canc Ctr, New Haven, CT USA

[4] Stanford Univ, Dept Radiat Oncol, Palo Alto, CA 94304 USA

[5] Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15260 USA

[6] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15260 USA

[7] UPMC Hillman Canc Ctr, Pittsburgh, PA 15232 USA

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2019年 / 16卷 / 11期

关键词：

SQUAMOUS-CELL CARCINOMA; TRANSORAL ROBOTIC SURGERY; LOCALLY-ADVANCED HEAD; QUALITY-OF-LIFE; INTENSITY-MODULATED RADIOTHERAPY; SENTINEL NODE BIOPSY; STAGE NASOPHARYNGEAL CARCINOMA; GASTROSTOMY TUBE DEPENDENCE; III RANDOMIZED-TRIAL; HUMAN-PAPILLOMAVIRUS;

D O I：

10.1038/s41571-019-0227-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck cancers are a heterogeneous collection of malignancies of the upper aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the changing therapeutic landscape of head and neck squamous cell carcinomas (HNSCCs) that can arise in the oral cavity, oropharynx, hypopharynx and larynx. We highlight developments in surgical and non-surgical therapies (mainly involving the combination of radiotherapy and chemotherapy), outlining how these treatments are being used in the current era of widespread testing for the presence of human papillomavirus infection in patients with HNSCC. Finally, we describe the clinical trials that led to the approval of the first immunotherapeutic agents for HNSCC, and discuss the development of strategies to decrease the toxicity of different treatment modalities.

引用

页码：669 / 683

页数：15

共 163 条

[1] Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 [J].

Agrawal, Nishant ;

Frederick, Mitchell J. ;

Pickering, Curtis R. ;

Bettegowda, Chetan ;

Chang, Kyle ;

Li, Ryan J. ;

Fakhry, Carole ;

Xie, Tong-Xin ;

Zhang, Jiexin ;

Wang, Jing ;

Zhang, Nianxiang ;

El-Naggar, Adel K. ;

Jasser, Samar A. ;

Weinstein, John N. ;

Trevino, Lisa ;

Drummond, Jennifer A. ;

Muzny, Donna M. ;

Wu, Yuanqing ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Westra, William H. ;

Koch, Wayne M. ;

Califano, Joseph A. ;

Gibbs, Richard A. ;

Sidransky, David ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

Papadopoulos, Nickolas ;

Wheeler, David A. ;

Kinzler, Kenneth W. ;

Myers, Jeffrey N. .

SCIENCE, 2011, 333 (6046) :1154-1157

[2] A Prospective Evaluation of Short-Term Dysphagia After Transoral Robotic Surgery for Squamous Cell Carcinoma of the Oropharynx [J].

Albergotti, William G. ;

Jordan, Jessica ;

Anthony, Keely ;

Abberbock, Shira ;

Wasserman-Wincko, Tamara ;

Kim, Seungwon ;

Ferris, Robert L. ;

Duvvuri, Umamaheswar .

CANCER, 2017, 123 (16) :3132-3140

[3] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[4] Sentinel Node Biopsy in Head and Neck Squamous Cell Cancer: 5-Year Follow-Up of a European Multicenter Trial [J].

Alkureishi, Lee W. T. ;

Ross, Gary L. ;

Shoaib, Taimur ;

Soutar, David S. ;

Robertson, A. Gerry ;

Thompson, Richard ;

Hunter, Keith D. ;

Sorensen, Jens A. ;

Thomsen, Jorn ;

Krogdahl, Annelise ;

Alvarez, Julio ;

Barbier, Luis ;

Santamaria, Joseba ;

Poli, Tito ;

Sesenna, Enrico ;

Kovacs, Adorjan F. ;

Gruenwald, Frank ;

Barzan, Luigi ;

Sulfaro, Sandro ;

Alberti, Franco .

ANNALS OF SURGICAL ONCOLOGY, 2010, 17 (09) :2459-2464

[5] Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer [J].

Ang, K. Kian ;

Harris, Jonathan ;

Wheeler, Richard ;

Weber, Randal ;

Rosenthal, David I. ;

Nguyen-Tan, Phuc Felix ;

Westra, William H. ;

Chung, Christine H. ;

Jordan, Richard C. ;

Lu, Charles ;

Kim, Harold ;

Axelrod, Rita ;

Silverman, C. Craig ;

Redmond, Kevin P. ;

Gillison, Maura L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (01) :24-35

[6]

[Anonymous], 2017, HEAD NECK

[7]

[Anonymous], FDA APPR EXP US GARD

[8]

[Anonymous], 2017, AJCC CANC STAGING MA

[9]

[Anonymous], ANN ONCOL

[10]

[Anonymous], 510K SUMM MEDR FLEX

← 1 2 3 4 5 6 7 8 9 10 →