Composite nanofiber of bioactive glass nanofiller incorporated poly(lactic acid) for bone regeneration

被引：53
作者：
Noh, Kyung-Tae [2 ,3 ,4 ]
Lee, Hye-Young [2 ,3 ,4 ]
Shin, Ueon-Sang [2 ,3 ,4 ]
Kim, Hae-Won [1 ,2 ,3 ,4 ]
机构：
[1] Dankook Univ, Sch Dent, Dept Biomat Sci, Seoul, South Korea
[2] Dankook Univ, Grad Sch, Dept Nanobiomed Sci, Seoul, South Korea
[3] Dankook Univ, Grad Sch, WCU Res Ctr, Seoul, South Korea
[4] Dankook Univ, Inst Tissue Regenerat Engn ITREN, Seoul, South Korea
来源：
MATERIALS LETTERS | 2010年 / 64卷 / 07期
关键词：
Nanofiber; Composites; Bioactivity; Biomaterials; TISSUE; MEMBRANE; FIBERS;
D O I：
10.1016/j.matlet.2010.01.014
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A novel composite nanofiber of poly(lactic acid) (PLA) incorporated with the nanocomponent of bioactive glass was exploited using an electrospinning method. Small concentrations of the bioactive glass phase added up to 10% facilitated the generation of a nanofibrous matrix with hundreds of nanometers in diameter without a formation of beads. The addition of the bioactive glass phase greatly enhanced the in vitro apatite formation on the nanofiber surface under a body simulating medium. Osteoblastic cells were demonstrated to adhere well on the composite nanofiber and grow actively with culturing time, suggesting its usefulness as a supporting matrix for the hard tissue regeneration. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：802 / 805
页数：4
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