Infiltrating T-cell abundance combined with EMT-related gene expression as a prognostic factor of colon cancer

被引:9
|
作者
Huang, Xiaowei [1 ]
Chen, Chan [2 ]
Xu, Yajing [1 ]
Shen, Lanxiao [3 ]
Chen, Yi [4 ]
Su, Huafang [1 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Wenzhou, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Geriatr Med, Wenzhou, Peoples R China
[3] Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiotherapy Ctr, Wenzhou, Peoples R China
[4] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
基金
中国国家自然科学基金;
关键词
Colon cancer; EMT; T-cells; immune checkpoint blockade; survival; EPITHELIAL-MESENCHYMAL TRANSITION; COLORECTAL-CANCER; SURVIVAL; METASTASIS; MICROENVIRONMENT; MIGRATION; SUBTYPES; THERAPY; ZEB1; TREG;
D O I
10.1080/21655979.2021.1939618
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
EMT-related gene expression reportedly exhibits correlation with the anti-tumor immunity of T cells. In the present study, we explored the factors that might affect the efficacy of immunotherapy in colon cancer with treatment. In this regard, RNA-seq and clinical data of 469 colon cancer samples derived from the Cancer Genome Atlas (TCGA) database were used to calculate infiltrating T-cell abundance (ITA), to illustrate a pathway enrichment analysis, and to construct Cox proportional hazards (CPH) regression models. Subsequently, the RNA-seq and clinical data of 177 colon cancer samples derived from the GSE17536 cohort were used to validate the CPH regression models. We found that ITA showed correlation with EMT-related gene expression, and that it was not an independent prognostic factor for colon cancer. However, upon comparison of two groups with the same ITA, higher EMT expression helped predicted a worse prognosis, whereas a higher ITA could help predict a better prognosis upon comparison of two groups with the same EMT. Additionally, seven genes were found to be statistically related to the prognosis of patients with colon cancer. These results suggest that the balance between ITA and EMT-related gene expression is conducive to the prognosis of patients with colon cancer, and TPM1 is necessary to further explore the common target genes of immune checkpoint blockade.
引用
收藏
页码:2688 / 2701
页数:14
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