Modelling epilepsy in the mouse: challenges and solutions

被引:46
作者
Marshall, Grant F. [1 ,2 ]
Gonzalez-Sulser, Alfredo [2 ,3 ]
Abbott, Catherine M. [1 ,2 ]
机构
[1] Univ Edinburgh, Western Gen Hosp, Ctr Genom & Expt Med, MRC,Inst Genet & Mol Med, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland
[2] Univ Edinburgh, Simons Initiat Developing Brain, Edinburgh EH8 9XD, Midlothian, Scotland
[3] Univ Edinburgh, Ctr Discovery Brain Sci, 1 George Sq, Edinburgh EH8 9XD, Midlothian, Scotland
关键词
Mouse; Epilepsy; Induced seizures; Genetic models; TRANSLATIONAL TASK-FORCE; NEW-ONSET EPILEPSY; SEIZURE SUSCEPTIBILITY; ANTIEPILEPTIC DRUGS; TUBEROUS SCLEROSIS; EILAT CONFERENCE; PROGRESS REPORT; CAENORHABDITIS-ELEGANS; NEURONAL PLASTICITY; DEFICIENCY SYNDROME;
D O I
10.1242/dmm.047449
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In most mouse models of disease, the outward manifestation of a disorder can be measured easily, can be assessed with a trivial test such as hind limb clasping, or can even be observed simply by comparing the gross morphological characteristics of mutant and wild-type littermates. But what if we are trying to model a disorder with a phenotype that appears only sporadically and briefly, like epileptic seizures? The purpose of this Review is to highlight the challenges of modelling epilepsy, in which the most obvious manifestation of the disorder, seizures, occurs only intermittently, possibly very rarely and often at times when the mice are not under direct observation. Over time, researchers have developed a number of ways in which to overcome these challenges, each with their own advantages and disadvantages. In this Review, we describe the genetics of epilepsy and the ways in which genetically altered mouse models have been used. We also discuss the use of induced models in which seizures are brought about by artificial stimulation to the brain of wild-type animals, and conclude with the ways these different approaches could be used to develop a wider range of anti-seizure medications that could benefit larger patient populations.
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页数:16
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