Resistance against anti-CD19 and anti-BCMA CAR T cells: Recent advances and coping strategies

被引：16
作者：
Atilla, Pinar Ataca [1 ]
Atilla, Erden [2 ]
机构：
[1] Ankara Univ, Stem Cell Inst, Ankara, Turkey
[2] Mersin City Hosp, Dept Hematol, Mersin, Turkey
来源：
TRANSLATIONAL ONCOLOGY | 2022年 / 22卷
关键词：
Chimeric antigen receptor T cells; Resistance; Immunotherapy; CD19; BCMA; ACUTE LYMPHOBLASTIC-LEUKEMIA; B-CELL; MULTIPLE-MYELOMA; RECEPTOR; THERAPY; IMMUNOTHERAPY; MALIGNANCIES; REMISSIONS; EXHAUSTION; APOPTOSIS;
D O I：
10.1016/j.tranon.2022.101459
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chimeric antigen receptor T (CAR T) cell therapy is a new treatment paradigm that has revolutionized the treatment of CD19-positive B cell malignancies and BCMA-positive plasma cell malignancies. The response rates are highly impressive in comparison to historical cohorts, but the responses are not durable. The most recent results from pivotal trials show that current CAR T cell products fail to demonstrate optimal long-term disease control. Resistance to CAR T cells is related to CAR structure, T cell factors, tumor factors and the immunosuppressive microenvironment. Novel strategies are needed following failure with CAR T cell treatment. In this review, we discuss the resistance mechanisms to CAR T cell treatment according to disease and the emerging strategies to overcome resistance.
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页数：9
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