Resistance against anti-CD19 and anti-BCMA CAR T cells: Recent advances and coping strategies

被引：16

作者：

Atilla, Pinar Ataca ^{[1
]}

Atilla, Erden ^{[2
]}

机构：

[1] Ankara Univ, Stem Cell Inst, Ankara, Turkey

[2] Mersin City Hosp, Dept Hematol, Mersin, Turkey

来源：

TRANSLATIONAL ONCOLOGY | 2022年 / 22卷

关键词：

Chimeric antigen receptor T cells; Resistance; Immunotherapy; CD19; BCMA; ACUTE LYMPHOBLASTIC-LEUKEMIA; B-CELL; MULTIPLE-MYELOMA; RECEPTOR; THERAPY; IMMUNOTHERAPY; MALIGNANCIES; REMISSIONS; EXHAUSTION; APOPTOSIS;

D O I：

10.1016/j.tranon.2022.101459

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chimeric antigen receptor T (CAR T) cell therapy is a new treatment paradigm that has revolutionized the treatment of CD19-positive B cell malignancies and BCMA-positive plasma cell malignancies. The response rates are highly impressive in comparison to historical cohorts, but the responses are not durable. The most recent results from pivotal trials show that current CAR T cell products fail to demonstrate optimal long-term disease control. Resistance to CAR T cells is related to CAR structure, T cell factors, tumor factors and the immunosuppressive microenvironment. Novel strategies are needed following failure with CAR T cell treatment. In this review, we discuss the resistance mechanisms to CAR T cell treatment according to disease and the emerging strategies to overcome resistance.

引用

页数：9

共 135 条

[1] Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study
Abramson, Jeremy S.
Palomba, M. Lia
Gordon, Leo I.
Lunning, Matthew A.
Wang, Michael
Arnason, Jon
Mehta, Amitkumar
Purev, Enkhtsetseg
Maloney, David G.
Andreadis, Charalambos
Sehgal, Alison
Solomon, Scott R.
Ghosh, Nilanjan
Albertson, Tina M.
Garcia, Jacob
Kostic, Ana
Mallaney, Mary
Ogasawara, Ken
Newhall, Kathryn
Kim, Yeonhee
Li, Daniel
Siddiqi, Tanya
[J]. LANCET, 2020, 396 (10254) : 839 - 852
[2] Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains
Alabanza, Leah
Pegues, Melissa
Geldres, Claudia
Shi, Victoria
Wiltzius, Jed J. W.
Sievers, Stuart A.
Yang, Shicheng
Kochenderfer, James N.
[J]. MOLECULAR THERAPY, 2017, 25 (11) : 2452 - 2465
[3] T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma
Ali, Syed Abbas
Shi, Victoria
Maric, Irina
Wang, Michael
Stroncek, David F.
Rose, Jeremy J.
Brudno, Jennifer N.
Stetler-Stevenson, Maryalice
Feldman, Steven A.
Hansen, Brenna G.
Fellowes, Vicki S.
Hakim, Frances T.
Gress, Ronald E.
Kochenderfer, James N.
[J]. BLOOD, 2016, 128 (13) : 1688 - 1700
[4] Senolytic CAR T cells reverse senescence-associated pathologies
Amor, Corina
Feucht, Judith
Leibold, Josef
Ho, Yu-Jui
Zhu, Changyu
Alonso-Curbelo, Direna
Mansilla-Soto, Jorge
Boyer, Jacob A.
Li, Xiang
Giavridis, Theodoros
Kulick, Amanda
Houlihan, Shauna
Peerschke, Ellinor
Friedman, Scott L.
Ponomarev, Vladimir
Piersigilli, Alessandra
Sadelain, Michel
Lowe, Scott W.
[J]. NATURE, 2020, 583 (7814) : 127 - +
[5] Amrolia P.J., 2018, P PAPER PRESENTED AM
[6] Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells
Bachem, Annabel
Makhlouf, Christina
Binger, Katrina J.
de Souza, David P.
Tull, Deidra
Hochheiser, Katharina
Whitney, Paul G.
Fernandez-Ruiz, Daniel
Dahling, Sabrina
Kastemuller, Wolfgang
Jonsson, Johanna
Gressier, Elise
Lew, Andrew M.
Perdomo, Carolina
Kupz, Andreas
Figgett, William
Mackay, Fabienne
Oleshansky, Moshe
Russ, Brendan E.
Parish, Ian A.
Kallies, Axel
McConville, Malcolm J.
Tumer, Stephen J.
Gebhardt, Thomas
Bedoui, Sammy
[J]. IMMUNITY, 2019, 51 (02) : 285 - +
[7] Ciltacabtagene autoleucel, a B-cell maturation antigendirected chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study
Berdeja, Jesus G.
Madduri, Deepu
Usmani, Saad Z.
Jakubowiak, Andrzej
Agha, Mounzer
Cohen, Adam D.
Stewart, A. Keith
Hari, Parameswaran
Htut, Myo
Lesokhin, Alexander
Deol, Abhinav
Munshi, Nikhil C.
O'Donnell, Elizabeth
Avigan, David
Singh, Indrajeet
Zudaire, Enrique
Yeh, Tzu-Min
Allred, Alicia J.
Olyslager, Yunsi
Banerjee, Arnob
Jackson, Carolyn C.
Goldberg, Jenna D.
Schecter, Jordan M.
Deraedt, William
Zhuang, Sen Hong
Infante, Jeffrey
Geng, Dong
Wu, Xiaoling
Carrasco-Alfonso, Marlene J.
Akram, Muhammad
Hossain, Farah
Rizvi, Syed
Fan, Frank
Lin, Yi
Martin, Thomas
Jagannath, Sundar
[J]. LANCET, 2021, 398 (10297) : 314 - 324
[8] Boucher JC., 2021, CANCER IMMUNOL RES, V9, P62, DOI [DOI 10.1158/2326-6066.CIR-20-0253, 10.1158/2326-6066.CIR-20-0253]
[9] The Optimal Antigen Response of Chimeric Antigen Receptors Harboring the CD3ζ Transmembrane Domain Is Dependent upon Incorporation of the Receptor into the Endogenous TCR/CD3 Complex
Bridgeman, John S.
Hawkins, Robert E.
Bagley, Steve
Blaylock, Morgan
Holland, Mark
Gilham, David E.
[J]. JOURNAL OF IMMUNOLOGY, 2010, 184 (12) : 6938 - 6949
[10] Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease
Brudno, Jennifer N.
Somerville, Robert P. T.
Shi, Victoria
Rose, Jeremy J.
Halverson, David C.
Fowler, Daniel H.
Gea-Banacloche, Juan C.
Pavletic, Steven Z.
Hickstein, Dennis D.
Lu, Tangying L.
Feldman, Steven A.
Iwamoto, Alexander T.
Kurlander, Roger
Maric, Irina
Goy, Andre
Hansen, Brenna G.
Wilder, Jennifer S.
Blacklock-Schuver, Bazetta
Hakim, Frances T.
Rosenberg, Steven A.
Gress, Ronald E.
Kochenderfer, James N.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (10) : 1112 - +

← 1 2 3 4 5 6 7 8 9 10 →