Development and Validation of a UV-Spectrophotometric Method for Quantitative Determination of Benzene Fragments in Benzyl Esters of Heparin

被引：2

作者：

Matveev, A. V. ^{[1
]}

Zhavoronok, E. S. ^{[1
,2
]}

Frumin, L. E. ^{[1
]}

Yur'eva, K. P. ^{[1
]}

Grebenkina, L. E. ^{[1
]}

Prokorov, D. I. ^{[1
]}

Panov, A. V. ^{[1
,2
]}

Kedik, S. A. ^{[1
,2
]}

机构：

[1] MIREA Russian Technol Univ, MV Lomonosov Inst Fine Chem Technol, 86 Vernadskogo Prosp, Moscow 119571, Russia

[2] LLC Inst Pharmaceut Technol, 21-32 Skolkovskoe Sh, Moscow 121353, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2021年 / 55卷 / 02期

关键词：

low-molecular-weight heparin; content of benzyl fragments; UV spectrophotometry; heparin benzyl ester; unfractionated heparin;

D O I：

10.1007/s11094-021-02382-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new UV-spectrophotometric method for determining the concentration of benzyl fragments in heparin benzyl esters is proposed. The method was validated for linearity, accuracy, and precision in terms of repeatability and intralaboratory reproducibility. The method is intended to characterize heparin benzyl esters, which are intermediates in the synthesis of low-molecular-weight heparin via hydrolytic depolymerization of high-molecular-weight heparin.

引用

页码：197 / 201

页数：5

共 50 条

[1] Development and Validation of a UV-Spectrophotometric Method for Quantitative Determination of Benzene Fragments in Benzyl Esters of Heparin
A. V. Matveev
E. S. Zhavoronok
L. E. Frumin
K. P. Yur’eva
L. E. Grebenkina
D. I. Prokorov
A. V. Panov
S. A. Kedik
Pharmaceutical Chemistry Journal, 2021, 55 : 197 - 201
[2] Development and Validation of the UV-Spectrophotometric Method for the Determination of Cordycepin, a Nucleoside
Kondapalli Vamsi Krishna
Jyothis Devasia
Alok Malaviya
Journal of Applied Spectroscopy, 2024, 91 : 228 - 235
[3] Development and Validation of the UV-Spectrophotometric Method for the Determination of Cordycepin, a Nucleoside
Krishna, Kondapalli Vamsi
Devasia, Jyothis
Malaviya, Alok
JOURNAL OF APPLIED SPECTROSCOPY, 2024, 91 (01) : 228 - 235
[4] Development and Validation of a UV-Spectrophotometric Method for Determination of Flucloxacillin Sodium in Capsules
Fiorentino, Flavia A. M.
Salgado, Herida R. N.
CURRENT PHARMACEUTICAL ANALYSIS, 2012, 8 (01) : 101 - 106
[5] DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CIPROFLOXACIN AND CURCUMIN IN BULK POWDER
Sanjay, Shailendra Suryawanshi
Kavalapure, Rohini
Palled, M. S.
Alegaon, S. G.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2020, 11 (03): : 1161 - 1166
[6] Quantitative UV-Spectrophotometric Determination of Ribavirin
Kienskaya K.I.
Il’yushenko E.V.
Sardushkin M.V.
Guznova N.Y.
Koldaeva T.Y.
Kusmaev A.M.
Ibragimova R.R.
Belova I.A.
Kukharenko A.V.
Shaposhnikova L.I.
Zav’yalova O.V.
Avramenko G.V.
Pharmaceutical Chemistry Journal, 2019, 53 (2) : 175 - 177
[7] DEVELOPMENT AND VALIDATION OF A UV-SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF PHENIRAMINE MALEATE AND ITS STABILITY STUDIES
Raghu, M. S.
Basavaiah, K.
Ramesh, P. J.
Abdulrahman, Sameer A. M.
Vinay, K. B.
JOURNAL OF APPLIED SPECTROSCOPY, 2012, 79 (01) : 131 - 138
[8] Development and validation of a UV-spectrophotometric method for the determination of pheniramine maleate and its stability studies
M. S. Raghu
K. Basavaiah
P. J. Ramesh
Sameer A. M. Abdulrahman
K. B. Vinay
Journal of Applied Spectroscopy, 2012, 79 : 131 - 138
[9] Development and Validation of a Stability Indicating UV-Spectrophotometric Assay Method for the Determination of Naratriptan Hydrochloride
Gupta, Ashutosh
Kumar, Jatin
Narang, Jasjeet Kaur
Verma, Surajpal
Singh, Harmanpreet
Haque, Anzarul
PERTANIKA JOURNAL OF SCIENCE AND TECHNOLOGY, 2019, 27 (02): : 933 - 941
[10] Development and validation of UV-spectrophotometric method for the estimation of hydroxychloroquine sulphate
Singh, Amit
Roopkishora
Sharma, Pradeep Kumar
Gupta, Ramji
Mondal, Nita
Kumar, Sokindra
Kumar, Mukesh
INDIAN JOURNAL OF CHEMICAL TECHNOLOGY, 2016, 23 (03) : 237 - 239

← 1 2 3 4 5 →