Sequenced elimination-reduction and elimination-cyclopropanation reactions of 2,3-epoxyamides promoted by samarium diiodide. Synthesis of 2,3-dideuterioamides and cyclopropanamides

被引：13

作者：

Concellon, JA ^{[1
]}

Huerta, M ^{[1
]}

Bardales, E ^{[1
]}

机构：

[1] Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain

来源：

TETRAHEDRON | 2004年 / 60卷 / 44期

关键词：

samariurn diiodide; sequenced reactions; deuterium; saturated amides; cyclopropanamides;

D O I：

10.1016/j.tet.2004.07.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An easy and general sequenced elimination/reduction or elimination/cyclopropanation process promoted by samarium diiodide or/and CH2I2/Sm provide an efficient method for synthesising 2,3-dideuterioamides 3 or cyclopropanamides 8, respectively. The transformations take place in high yields and with total or high selectivity from the easily available 2,3-epoxyamides. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：10059 / 10065

页数：7

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