Design and development of a method for the reduction of infectious pathogen load and inactivation of white blood cells in whole blood products

被引:66
作者
Goodrich, Raymond P. [1 ]
Doane, Suzann [1 ]
Reddy, Heather L. [1 ]
机构
[1] CaridianBCT Biotechnol LLC, Lakewood, CO 80215 USA
关键词
Pathogen reduction; Whole blood; Riboflavin; UV-light; FRESH-FROZEN PLASMA; BACTERIAL-CONTAMINATION; FUTURE-TRENDS; RIBOFLAVIN; TECHNOLOGY; COMPONENTS; SURVIVAL;
D O I
10.1016/j.biologicals.2009.10.016
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The use of blood components has been a staple of transfusion medicine for several decades Technologies for the processing and handling of blood, including separation of components from whole blood, are very well developed Relative to blood safety, methods to detect the presence of pathogens and reduce the levels of donor white blood cells from whole blood are also well established in routine practice. The advantages which exist for the handling of whole blood by these methods have, for various reasons, not extended to the field of pathogen reduction technology (PRT) PRT methods have been developed and are now in routine use in various locations for addressing single donor or pooled plasma and platelet products. Several methods have also been in experimental development for the treatment of red blood cells as a separate component. The ability to treat whole blood in a fashion that would allow a single pathogen reduction and white blood cell inactivation step, to be followed by use of the product in the form of whole blood or separation into components, would afford several benefits from both a logistical and practical standpoint. This manuscript describes development efforts using a photochemical PRT method employing riboflavin and UV-Light (Mirasol (R) PRT). (C) 2009 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved
引用
收藏
页码:20 / 30
页数:11
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