Gut Microbiome and Sex Bias in Autism Spectrum Disorders

被引：7

作者：

El-Ansary, Afaf ^{[1
,2
]}

Bhat, Ramesa Shafi ^{[3
]}

Zayed, Naima ^{[4
]}

机构：

[1] King Saud Univ, Female Ctr Sci & Med Studies, Cent Lab, Riyadh, Saudi Arabia

[2] Autism Res & Treatment Ctr, Riyadh, Saudi Arabia

[3] King Saud Univ, Sci Coll, Biochem Dept, Riyadh, Saudi Arabia

[4] Natl Res Ctr, Therapeut Chem Dept, Cairo, Egypt

来源：

CURRENT BEHAVIORAL NEUROSCIENCE REPORTS | 2020年 / 7卷 / 01期

关键词：

Autism spectrum disorders; Sex bias; Gut microbiota; Leaky gut; Glutamate excitotoxicity; INTESTINAL PERMEABILITY; EXPRESSION; CHILDREN; ZONULIN; INFLAMMATION; PREVALENCE; INCREASES; ATTENTION; BEHAVIOR; DEFICITS;

D O I：

10.1007/s40473-020-00197-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Purpose of ReviewAutism spectrum disorders (ASD) express as impaired social interactions and stereotypes. The gut microbiome which is remarkably different in ASD compared with controls may contribute to the sex bias of this disorder, with females being less vulnerable to clinically present autism. This review aims to understand the role of gut microbiota and female sex hormone in the sex bias of autism.Recent FindingsRecent evidence proved that transplanted gut microbiota from autistic donors but not healthy controls into germ-free mice were effective in inducing autistic features. Moreover selective probiotic known to be more abundant in females than males was effective as a treatment strategy.SummaryThe higher autistic phenotypes in males compared with females could be attributed to the protective effect of estrogen, the higher diversity and predominance of probiotics in females, the lower liability of females to develop leaky gut, neuroinflammation, and excitotoxicity as etiological mechanisms.

引用

页码：22 / 31

页数：10

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