Novel BODIPY-Based Fluorescence Turn-on Sensor for Fe3+ and Its Bioimaging Application in Living Cells

被引:161
|
作者
Sui, Binglin [1 ]
Tang, Simon [1 ]
Liu, Taihong [1 ]
Kim, Bosung [1 ]
Belfield, Kevin D. [1 ,2 ,3 ]
机构
[1] Univ Cent Florida, Dept Chem, Orlando, FL 32816 USA
[2] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA
[3] Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710062, Peoples R China
基金
美国国家科学基金会;
关键词
iron(III); fluorescent sensor; BODIPY; cryptand; cell imaging; metal ion sensor; IRON; IRON(III); DESIGN; PROBES; IONS;
D O I
10.1021/am506262u
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
A novel boron-dipyrromethene (BODIPY) based fluorescence turn-on sensor for detecting Fe3+ in aqueous media is reported with 23-fold fluorescence enhancement. The sensor is comprised of a combination of BODIPY fluorophore and a new Fe3+-recognizing cryptand that exhibits high selectivity, sensitivity, and reversibility toward Fe3+ detection. Cell imaging studies demonstrate that this sensor is capable of sensing Fe3+ in living cells.
引用
收藏
页码:18408 / 18412
页数:5
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