Efficacy of a biobehavioral intervention for hot flashes: a randomized controlled pilot study

被引:17
作者
Barton, Debra L. [1 ]
Schroeder, Kelliann C. Fee [2 ]
Banerjee, Tanima [1 ]
Wolf, Sherry [2 ]
Keith, Timothy Z. [3 ]
Elkins, Gary [4 ]
机构
[1] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA
[2] Mayo Clin, Rochester, MN USA
[3] Univ Texas Austin, Austin, TX 78712 USA
[4] Baylor Univ, Waco, TX 76798 USA
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2017年 / 24卷 / 07期
关键词
Breast cancer survivorship; Hot flashes/behavioral intervention; Hot flashes/drug therapy; Hot flashes/hypnosis; Hot flashes/nonpharmacologic treatment; Menopause; Postmenopause; Quality of life; QUALITY-OF-LIFE; BREAST-CANCER; MENOPAUSAL SYMPTOMS; VASOMOTOR SYMPTOMS; POSTMENOPAUSAL WOMEN; NIGHT SWEATS; PHASE-III; MANAGEMENT; THERAPY; VENLAFAXINE;
D O I
10.1097/GME.0000000000000837
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The need for effective nonhormonal treatments for hot flash management without unwanted side effects continues. The primary aim of this pilot study was to evaluate the effect of combining a nonhormonal pharmacologic agent with a behavioral treatment for hot flash reduction. Methods: Seventy-one postmenopausal women were randomized to one of four groups: venlafaxine 75 mg + hypnosis (VH) versus venlafaxine 75 mg + sham hypnosis (VSH) versus a placebo pill + hypnosis (PH) versus placebo pill + sham hypnosis (PSH). Women recorded hot flash severity and frequency in a daily diary, in real time. The intrapatient difference in hot flash score (frequency + severity) at 8 weeks was analyzed using a General Estimating Equation model, using VSH as the referent arm, controlling for baseline hot flashes. Results: The active arms including PH or VH were not statistically significantly different than VSH (P = 0.34, P = 0.05, respectively). Women in each active arm reported hot flash reductions of about 50%, with the PSH group reporting a 25% reduction. Women receiving the PSH reported statistically significantly smaller reductions in hot flash score than women in the referent VSH arm (P = 0.001). There were no significant negative side effects during the course of the study. Conclusions: Hypnosis alone reduced hot flashes equal to venlafaxine alone, but the combination of hypnosis and venlafaxine did not reduce hot flashes more than either treatment alone. More research is needed to clarify whether combining hypnosis with a different antidepressant would provide synergistic benefits.
引用
收藏
页码:774 / 782
页数:9
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