Fatty acid metabolism in the regulation of T cell function

被引:333
作者
Lochner, Matthias [1 ]
Berod, Luciana
Sparwasser, Tim
机构
[1] Ctr Expt & Clin Infect Res, TWINCORE, Joint Venture Med Sch Hannover MHH, Inst Infect Immunol, Hannover, Germany
关键词
T cells; fatty acids; fatty acid oxidation; fatty acid synthesis; mTOR; ACC; AMPK; ACTIVATED PROTEIN-KINASE; ACETYL-COA CARBOXYLASE-2; VERSUS-HOST-DISEASE; BREAST-CANCER CELLS; DE-NOVO LIPOGENESIS; ATP-CITRATE LYASE; SKELETAL-MUSCLE; 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE; AMPK PHOSPHORYLATION; HISTONE ACETYLATION;
D O I
10.1016/j.it.2014.12.005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The specific regulation of cellular metabolic processes is of major importance for directing immune cell differentiation and function. We review recent evidence indicating that changes in basic cellular lipid metabolism have critical effects on T cell proliferation and cell fate decisions. While induction of de novo fatty acid (FA) synthesis is essential for activation-induced proliferation and differentiation of effector T cells, FA catabolism via beta-oxidation is important for the development of CD8(+) T cell memory as well as for the differentiation of CD4(+) regulatory T cells. We consider the influence of lipid metabolism and metabolic intermediates on the regulation of signaling and transcriptional pathways via post-translational modifications, and discuss how an improved understanding of FA metabolism may reveal strategies for manipulating immune responses towards therapeutic outcomes.
引用
收藏
页码:81 / 91
页数:11
相关论文
共 96 条
[1]   Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets [J].
Abu-Elheiga, L ;
Oh, WK ;
Kordari, P ;
Wakil, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10207-10212
[2]   The subcellular localization of acetyl-CoA carboxylase 2 [J].
Abu-Elheiga, L ;
Brinkley, WR ;
Zhong, L ;
Chirala, SS ;
Woldegiorgis, G ;
Wakil, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1444-1449
[3]   Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2 [J].
Abu-Elheiga, L ;
Matzuk, MM ;
Abo-Hashema, KAH ;
Wakil, SJ .
SCIENCE, 2001, 291 (5513) :2613-2616
[4]   Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation [J].
Akimzhanov, Askar M. ;
Yang, Xuexian O. ;
Dong, Chen .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (09) :5969-5972
[5]   mTOR regulates memory CD8 T-cell differentiation [J].
Araki, Koichi ;
Turner, Alexandra P. ;
Shaffer, Virginia Oliva ;
Gangappa, Shivaprakash ;
Keller, Susanne A. ;
Bachmann, Martin F. ;
Larsen, Christian P. ;
Ahmed, Rafi .
NATURE, 2009, 460 (7251) :108-U124
[6]   Essential role of CD8 palmitoylation in CD8 coreceptor function [J].
Arcaro, A ;
Grégoire, C ;
Boucheron, N ;
Stotz, S ;
Palmer, E ;
Malissen, B ;
Luescher, IF .
JOURNAL OF IMMUNOLOGY, 2000, 165 (04) :2068-2076
[7]   Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].
Arpaia, Nicholas ;
Campbell, Clarissa ;
Fan, Xiying ;
Dikiy, Stanislav ;
van der Veeken, Joris ;
deRoos, Paul ;
Liu, Hui ;
Cross, Justin R. ;
Pfeffer, Klaus ;
Coffer, Paul J. ;
Rudensky, Alexander Y. .
NATURE, 2013, 504 (7480) :451-+
[8]   AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis [J].
Bai, Aiping ;
Ma, Allan G. ;
Yong, Michael ;
Weiss, Carolyn R. ;
Ma, Yanbing ;
Guan, Qingdong ;
Bernstein, Charles N. ;
Peng, Zhikang .
BIOCHEMICAL PHARMACOLOGY, 2010, 80 (11) :1708-1717
[9]   Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide Ribonucleoside with Protective Effect in Dextran Sulfate Sodium-Induced Acute and Chronic Colitis [J].
Bai, Aiping ;
Yong, Michael ;
Ma, Allan G. ;
Ma, Yanbing ;
Weiss, Carolyn R. ;
Guan, Qingdong ;
Bernstein, Charles N. ;
Peng, Zhikang .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 333 (03) :717-725
[10]   Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells [J].
Battaglia, M ;
Stabilini, A ;
Roncarolo, MG .
BLOOD, 2005, 105 (12) :4743-4748