Polarized growth and organelle segregation in yeast: the tracks, motors, and receptors

被引：117
作者：
Bretscher, A [1 ]
机构：
[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA
来源：
JOURNAL OF CELL BIOLOGY | 2003年 / 160卷 / 06期
关键词：
polarity; transport; actin; myosin; vacuole;
D O I：
10.1083/jcb.200301035
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In yeast, growth and organelle segregation requires formin-dependent assembly of polarized actin cables. These tracks are used by myosin Vs to deliver secretory vesicles for cell growth, organelles for their segregation, and mRNA for fate determination. Several specific receptors have been identified that interact with the cargo-binding tails of the myosin Vs. A recent study implicates specific degradation in the bud of the vacuolar receptor, Vac17, as a mechanism for cell cycle-regulated segregation of this organelle.
引用
收藏
页码：811 / 816
页数：6
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