Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress

被引：20

作者：

Tsuru, Jusen ^{[1
]}

Tanaka, Yoshihiro ^{[1
]}

Ishitobi, Yoshinobu ^{[1
]}

Maruyama, Yoshihiro ^{[1
]}

Inoue, Ayako ^{[1
]}

Kawano, Aimi ^{[1
]}

Ikeda, Rie ^{[1
]}

Ando, Tomoko ^{[1
]}

Oshita, Harumi ^{[2
]}

Aizawa, Saeko ^{[1
]}

Masuda, Koji ^{[1
]}

Higuma, Haruka ^{[1
]}

Kanehisa, Masayuki ^{[1
]}

Ninomiya, Taiga ^{[1
]}

Akiyoshi, Jotaro ^{[1
]}

机构：

[1] Oita Univ, Dept Neuropsychiat, Fac Med, Oita 8795593, Japan

[2] Oita Univ, Fac Med, Dept Appl Linguist, Oita, Japan

来源：

NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2014年 / 10卷

关键词：

stress; brain-derived neurotrophic factor; cortisol; saliva; SALIVARY ALPHA-AMYLASE; ELECTRICAL-STIMULATION STRESS; ACTIVITY-DEPENDENT SECRETION; NEUROTROPHIC-FACTOR; SEX-DIFFERENCES; PSYCHOSOCIAL STRESS; CORTISOL RESPONSES; GENE POLYMORPHISM; MET ALLELE; PERSONALITY-TRAITS;

D O I：

10.2147/NDT.S68629

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Decreased expression of brain-derived neurotrophic factor (BDNF) is implicated in enhanced stress responses. The BDNF Val66Met polymorphism is associated with psychological changes; for example, carriers of the Met allele exhibit increased harm avoidance as well as a higher prevalence of depression and anxiety disorder. Methods: To analyze the effects of BDNF Val66Met on stress responses, we tested 226 university students (88 women and 138 men) using a social stress procedure (Trier Social Stress Test [TSST]) and an electrical stimulation stress test. Stress indices were derived from repeated measurements of salivary alpha-amylase, salivary cortisol, heart rate, and psychological testing during the stress tests. All subjects were genotyped for the Val66Met polymorphism (G196A). Results: A significant three-way interaction (time [3 levels] x BDNF [Val/Val, Val/Met, Met/Met]; P<0.05) was demonstrated that revealed different salivary cortisol responses in the TSST but not in electrical stimulation. Met/Met women had stronger cortisol responses than Val/Met and Val/Val individuals in the TSST. Met/Met men exhibited stronger salivary cortisol responses than Val/Met and Val/Val individuals in the TSST. Conclusion: These results indicate that a common, functionally significant polymorphism in BDNF had different effects on hypothalamic-pituitary-adrenocortical axis reactivity but not on sympathetic adrenomedullary reactivity in TSST and electrical stimulation tests.

引用

页码：2123 / 2133

页数：11

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