Hypotonic stress enhances slope conductivity of ATP-sensitive K+ channels activated pharmacologically

被引：2

作者：

Kocic, Ivan

Hirano, Yuji

Petrusewicz, Jacek

Hiraoka, Masayasu

机构：

[1] Med Univ Gdansk, Dept Pharmacol, PL-80204 Gdansk, Poland

[2] Tokyo Med & Dent Univ, Dept Cardiovasc Dis, Med Res Inst, Tokyo, Japan

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2007年 / 116卷 / 03期

关键词：

ATP-sensitive potassium channels; hypotonic stress; cell swelling; slope conductivity; patch clamp;

D O I：

10.1016/j.ijcard.2006.03.077

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this paper was to find out the effects of hypotonic stress on the slope conductivity of ATP-sensitive K+ channels. Using patch clamp technique, rilmakalim and pinacidil as the activators and glibenclamide as an inhibitor of mentioned channels, we have demonstrated that short hypotonic challenge doubled slope conductivity of exploring channels by augmentation of their open probability. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：423 / 424

页数：2

共 6 条

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