Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle

被引：88
作者：
Bailey, Leslie
Gylfe, Asa
Sundin, Charlotta
Muschiol, Sandra
Elofsson, Mikael
Nordstrom, Peter
Henriques-Normark, Birgitta
Lugert, Raimond
Waldenstrom, Anders
Wolf-Watz, Hans
Bergstrom, Sven [1 ]
机构：
[1] Umea Univ, Dept Mol Biol, SE-90187 Umea, Sweden
[2] Karolinska Inst, Swedish Inst Infect Dis Control & Microbiol, SE-1782 Stockholm, Sweden
[3] Karolinska Inst, Tumor Biol Ctr, SE-1782 Stockholm, Sweden
[4] Umea Univ, Dept Chem, SE-90347 Umea, Sweden
[5] Umea Univ, Dept Internal Med, SE-90187 Umea, Sweden
[6] Univ Gottingen, Dept Bacteriol, D-37075 Gottingen, Germany
来源：
FEBS LETTERS | 2007年 / 581卷 / 04期
关键词：
type III secretion; inhibitors; chemical genetics; Chlamydia; Yersinia;
D O I：
10.1016/j.febslet.2007.01.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Intracellular parasitism by Chlainydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated. p in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaidehydes that specifically blocks the T3S of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlaniydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：587 / 595
页数：9
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