An efficient approach to 3-oxoisoindoline-1-difluoroalkyl derivatives via a metal triflate-catalyzed Mannich/lactamization cascade reaction

被引：23

作者：

Chen, Tingting ^{[1
]}

Cai, Chun ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Coll Chem Engn, 200 Xiaolingwei, Nanjing 210094, Jiangsu, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2017年 / 41卷 / 07期

关键词：

SUBSTITUTED 3-OXOISOINDOLINE-1-CARBONITRILE DERIVATIVES; MUKAIYAMA-MANNICH REACTION; ONE-POT SYNTHESIS; C-F BOND; TRIFLUOROMETHYL KETONES; REFORMATSKY REACTION; RECEPTOR LIGANDS; HIGHLY EFFICIENT; ALDOL REACTION; SILYL ETHERS;

D O I：

10.1039/c6nj03813a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient approach for the synthesis of N-substituted 3-oxoisoindoline-1-difluoroalkyl derivatives via a one-pot cascade reaction has been developed. The reaction proceeded smoothly in the presence of In(OTf)(3) and afforded a broad scope of isoindolinones with moderate to good yields. Moreover, the reaction could be run on a gram-scale with comparable yield.

引用

页码：2519 / 2522

页数：4

共 58 条

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