Methods for linkage disequilibrium mapping in crops

被引：302

作者：

Mackay, Ian ^{[1
]}

Powell, Wayne ^{[1
]}

机构：

[1] NIAB, Cambridge CB3 0LE, England

来源：

TRENDS IN PLANT SCIENCE | 2007年 / 12卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.tplants.2006.12.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Linkage disequilibrium (LD) mapping in plants detects and locates quantitative trait loci (QTL) by the strength of the correlation between a trait and a marker. It offers greater precision in QTL location than family-based linkage analysis and should therefore lead to more efficient marker-assisted selection, facilitate gene discovery and help to meet the challenge of connecting sequence diversity with heritable phenotypic differences. Unlike family-based linkage analysis, LD mapping does not require family or pedigree information and can be applied to a range of experimental and non-experimental populations. However, care must be taken during analysis to control for the increased rate of false positive results arising from population structure and variety interrelationships. In this review, we discuss how suitable the recently developed alternative methods of LD mapping are for crops.

引用

页码：57 / 63

页数：7

共 45 条

[21] A low-cost open-source SNP genotyping platform for association mapping applications [J].