A comprehensive review on synthetic approach for antimalarial agents

被引：45

作者：

Kumar, Ajay ^{[1
]}

Paliwal, Deepika ^{[1
]}

Saini, Deepika ^{[1
]}

Thakur, Aman ^{[1
]}

Aggarwal, Shilpy ^{[2
]}

Kaushik, Dhirender ^{[1
]}

机构：

[1] Kurukshetra Univ, Inst Pharmaceut Sci, Kurukshetra 136119, Haryana, India

[2] RKSD PG Coll, Kaithal, Haryana, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 85卷

关键词：

Malaria; Plasmodium; Heterocyclic; Synthesis; Antimalarial; ONE-POT SYNTHESIS; IN-VITRO; POTENTIAL ANTIMALARIAL; PLASMODIUM-FALCIPARUM; PHARMACOLOGICAL EVALUATION; QUINOLINE ANTIMALARIALS; ANTIPLASMODIAL ACTIVITY; PYRAZOLINE DERIVATIVES; ANTIPARASITIC ACTIVITY; ANTIPROTOZOAL ACTIVITY;

D O I：

10.1016/j.ejmech.2014.07.084

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Malaria has emerged as a major health problem worldwide after the appearance of resistant strains of Plasmodium falciparum to the most of antimalarial drugs. The development of resistance by the parasite against first line as well as second line antimalarial drugs has drawn attention to develop new drugs to alleviate the disease burden. Therefore, there is a great need for new antimalarial drugs with improved attributes over older therapies. This review is primarily addressed to description of the recent advances in the synthesis of heterocyclic compound as antimalarial agents which can facilitate the development of more potent and effective antimalarial agents. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：147 / 178

页数：32

共 251 条

[1] Synthesis and evaluation of molluscicidal and larvicidal activities of some novel enaminones derived from 4-hydroxyquinolinones: Part IX [J].

Abass, M ;

Mostafa, BB .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (22) :6133-6144

[2]

Acharya B.N., 2010, U.S. Patent, Patent No. [20100197781 Al, 20100197781]

[3] Synthesis and antimalarial evaluation of 1, 3, 5-trisubstituted pyrazolines [J].

Acharya, Badri Narayan ;

Saraswat, Deepika ;

Tiwari, Mugdha ;

Shrivastava, Asish Kumar ;

Ghorpade, Ramarao ;

Bapna, Saroj ;

Kaushik, Mahabir Parshad .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (02) :430-438

[4] Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway [J].

Acharya, Badri Narayan ;

Saraswat, Deepika ;

Kaushik, Mahabir Parshad .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (12) :2840-2852

[5] Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents [J].

Agarwal, A ;

Srivastava, K ;

Puri, SK ;

Chauhan, PMS .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (22) :6226-6232

[6] Synthesis of substituted indole derivatives as a new class of antimalarial agents [J].

Agarwal, A ;

Srivastava, K ;

Puri, SK ;

Chauhan, PMS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (12) :3133-3136

[7] Antimalarial activity and synthesis of new trisubstituted pyrimidines [J].

Agarwal, A ;

Srivastava, K ;

Puri, SK ;

Chauhan, PMS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (12) :3130-3132

[8] Dibenzylideneacetone analogues as novel Plasmodium falciparum inhibitors [J].

Aher, Rahul Balasaheb ;

Wanare, Gajanan ;

Kawathekar, Neha ;

Kumar, Ravi Ranjan ;

Kaushik, Naveen Kumar ;

Sahal, Dinkar ;

Chauhan, Virander Singh .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (10) :3034-3036

[9]

Aissaoui H., 2011, PCT Int. Appl., Patent No. [2011083413 A1, 2011083413, WO2011083413 A1]

[10]

Aissaoui H., 2011, U.S. Patent, Patent No. [20110224210 Al, 20110224210]

← 1 2 3 4 5 6 7 8 9 10 →