The time to relapse correlates with the histopathological growth pattern in nodular lymphocyte predominant Hodgkin lymphoma

被引：32

作者：

Hartmann, Sylvia ^{[1
,2
]}

Pluetschow, Annette ^{[3
,4
]}

Mottok, Anja ^{[5
,6
,7
,8
]}

Bernd, Heinz-Wolfram ^{[9
]}

Feller, Alfred C. ^{[9
]}

Ott, German ^{[10
]}

Cogliatti, Sergio ^{[11
]}

Fend, Falko ^{[12
]}

Quintanilla-Martinez, Leticia ^{[12
]}

Stein, Harald ^{[13
]}

Klapper, Wolfram ^{[14
]}

Moeller, Peter ^{[15
]}

Rosenwald, Andreas ^{[5
,6
]}

Engert, Andreas ^{[3
,4
]}

Hansmann, Martin-Leo ^{[1
,2
,16
]}

Eichenauer, Dennis A. ^{[3
,4
]}

机构：

[1] Goethe Univ, Senckenberg Inst Pathol, Frankfurt, Germany

[2] Goethe Univ, Reference & Consultat Ctr Lymph Node & Lymphoma P, Frankfurt, Germany

[3] Univ Cologne, Ctr Integrated Oncol Aachen Bonn Cologne Dusseldo, Dept Internal Med 1, Cologne, Germany

[4] Univ Hosp Cologne, German Hodgkin Study Grp, Cologne, Germany

[5] Univ Wurzburg, Inst Pathol, Wurzburg, Germany

[6] Comprehens Canc Ctr CCC Mainfranken, Wurzburg, Germany

[7] Ulm Univ, Inst Human Genet, Ulm, Germany

[8] Ulm Univ, Med Ctr, Ulm, Germany

[9] Hematopathol Lubeck, Lubeck, Germany

[10] Robert Bosch Krankenhaus & Dr Margarete Fischer B, Dept Clin Pathol, Stuttgart, Germany

[11] Kantonsspital St Gallen, Inst Pathol, St Gallen, Switzerland

[12] Eberhard Karls Univ Tubingen, Inst Pathol, Tubingen, Germany

[13] Berlin Reference Ctr Lymphoma & Hematopathol, Pathodiagnost Berlin, Berlin, Germany

[14] Univ Hosp Schleswig Holstein, Hematopathol Sect & Lymph Node Registry, Inst Pathol, Campus Kiel, Kiel, Germany

[15] Univ Hosp Ulm, Inst Pathol, Ulm, Germany

[16] Frankfurt Inst Adv Studies, Frankfurt, Germany

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2019年 / 94卷 / 11期

关键词：

PROGNOSTIC IMPACT; TRANSFORMATION; DISEASE;

D O I：

10.1002/ajh.25607

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) can present with different histopathological growth patterns. The impact of these histopathological growth patterns on relapse characteristics is unknown. We therefore analyzed paired biopsies obtained at initial diagnosis and relapse from 33 NLPHL patients who had received first-line treatment within German Hodgkin Study Group (GHSG) trial protocols, and from a second cohort of 41 relapsed NLPHL patients who had been treated outside GHSG studies. Among the 33 GHSG patients, 21 patients presented with a typical growth pattern at initial diagnosis, whereas 12 patients had a variant histology. The histopathological growth patterns at initial diagnosis and at relapse were consistent in 67% of cases. A variant histology at initial diagnosis was associated with a shorter median time to lymphoma recurrence (2.8 vs 5.2 years; P = .0219). A similar tendency towards a shorter median time to lymphoma recurrence was observed for patients presenting with a variant histology at relapse, irrespective of the growth pattern at initial diagnosis. Results obtained from the 41 NLPHL patients who had been treated outside GHSG studies were comparable (median time to lymphoma recurrence for variant histology vs typical growth pattern at initial diagnosis: 1.5 vs 7.0 years). In conclusion, the histopathological growth pattern remains consistent at relapse in the majority of NLPHL cases, and has major impact on the time of relapse.

引用

页码：1208 / 1213

页数：6

共 15 条

[1] Transformation to Aggressive Lymphoma in Nodular Lymphocyte-Predominant Hodgkin's Lymphoma [J].