Pivotal regulators of tissue homeostasis and cancer: macrophages

被引：59
作者：
Chen, Yulei [1 ]
Zhang, Xiaobo [1 ]
机构：
[1] Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Peoples R China
来源：
EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2017年 / 6卷
基金：
中国国家自然科学基金;
关键词：
4Macrophage; Phenotype; Polarization; Homeostasis; Cancer; TUMOR-ASSOCIATED MACROPHAGES; UNDERLYING LINEAGE COMMITMENT; SUPPRESSOR-CELLS; TRANSCRIPTION FACTOR; GENE-EXPRESSION; INNATE IMMUNITY; M2; MACROPHAGES; TNF-ALPHA; T-CELLS; POLARIZATION;
D O I：
10.1186/s40164-017-0083-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Macrophages are an essential component of innate immunity and play a vital role in inflammation and host defense. Based on immunological responses, the macrophages are classified into "activated" macrophage (M1 macrophages) participating in the responses of type I helper T (Th1) cells to pathogens and "alternatively activated" macrophages (M2 macrophages) in response to interleukin (IL)-4 and IL-13. In this review, we discuss the origin, classification and function of macrophages. We also discuss the mechanisms underlying polarization of different macrophage subtypes, including transcriptional, epigenetic and post-transcriptional regulation.
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页数：8
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