Histone H1 alterations in cancer

被引：46
作者：
Scaffidi, Paola [1 ,2 ]
机构：
[1] Francis Crick Inst, Lincolns Inn Fields Lab, London WC2A 3LY, England
[2] UCL, UCL Canc Inst, London WC1E 6DD, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2016年 / 1859卷 / 03期
关键词：
Histone H1; Cancer; Mutations; Chromatin; Biomarker; Driver; DNA-DAMAGE RESPONSE; MESSENGER-RNA; HUMAN BREAST; PEDIATRIC GLIOBLASTOMA; DROSOPHILA-TRITHORAX; CHROMATIN-STRUCTURE; DRIVER MUTATIONS; TUMOR-SUPPRESSOR; ACUTE LEUKEMIAS; OVARIAN-CANCER;
D O I：
10.1016/j.bbagrm.2015.09.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chromatin-related proteins have emerged as important players in the initiation and maintenance of several types of cancer. In addition to the established role of histone-modifying enzymes and chromatin remodelers in promoting and sustaining malignant phenotypes, recent findings suggest that the basic components of chromatin, the his tone proteins, also suffer severe alterations in cancer and may contribute to the disease. Histopathological examination of clinical samples, characterization of the mutational landscape of various types of cancer and functional studies in cancer cell lines have highlighted the linker histone H1 both as a potential biomarker and a driver in cancer. This review summarizes H1 abnormalities in cancer identified by various approaches and critically discusses functional implications of such alterations, as well as potential mechanisms through which they may contribute to the disease. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albertiordan. (C) 2015 Elsevier B.V. All rights reserved.
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收藏
页码：533 / 539
页数：7
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