Intergenerational effect of short-term spaceflight in mice

被引：14

作者：

Yoshida, Keisuke ^{[1
,9
]}

Fujita, Shin-ichiro ^{[2
]}

Isotani, Ayako ^{[3
,10
]}

Kudo, Takashi ^{[4
,5
,6
]}

Takahashi, Satoru ^{[4
,5
,6
]}

Ikawa, Masahito ^{[3
,6
]}

Shiba, Dai ^{[6
,7
]}

Shirakawa, Masaki ^{[6
,7
]}

Muratani, Masafumi ^{[2
,6
]}

Ishii, Shunsuke ^{[1
,8
]}

机构：

[1] RIKEN, Cluster Pioneering Res, Tsukuba, Ibaraki 3050074, Japan

[2] Univ Tsukuba, Fac Med, Dept Genome Biol, Tsukuba, Ibaraki 3058575, Japan

[3] Osaka Univ, Res Inst Microbial Dis, Dept Expt Genome Res, Suita, Osaka 5650871, Japan

[4] Univ Tsukuba, Fac Med, Lab Anim Resource Ctr, Transborder Med Res Ctr, Tsukuba, Ibaraki 3058575, Japan

[5] Univ Tsukuba, Fac Med, Dept Anat & Embryol, Tsukuba, Ibaraki 3058575, Japan

[6] Japan Aerosp Explorat Agcy JAXA, Mouse Epigenet Project, ISS Kibo Expt, Tsukuba, Ibaraki, Japan

[7] JAXA, Human Spaceflight Technol Directorate, JEM Utilizat Ctr, Ibaraki 3058505, Japan

[8] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Funct Genom, Tsukuba, Ibaraki 3058577, Japan

[9] RIKEN, BioResource Res Ctr, Next Generat Human Dis Model Team, Tsukuba, Ibaraki 3050074, Japan

[10] Nara Inst Sci & Technol, Grad Sch Sci & Technol, 8916-5 Takayama Cho, Nara 6300192, Japan

来源：

ISCIENCE | 2021年 / 24卷 / 07期

关键词：

EPIGENETIC CHANGES; SPERMATOGENESIS; DYSFUNCTION; EXPRESSION; GENES;

D O I：

10.1016/j.isci.2021.102773

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, the effect on offspring has not been well studied in mammals. Here we investigated the effect of 35 days spaceflight on male germ cells. Male mice that had experienced spaceflight exhibit alterations in binding of transcription factor ATF7, a regulator of heterochromatin formation, on promoter regions in testis, as well as altered small RNA expression in spermatozoa. Offspring of space-traveling males exhibit elevated hepatic expression of genes related to DNA replication. These results indicate that spaceflight has intergenerational effect.

引用

页数：12

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