Human Polyomavirus Is Associated With Earlier Onset of Upper Urinary Tract Urothelial Carcinoma in Patients After Kidney Transplantation

被引:9
作者
Luo, H. L. [1 ,2 ]
Chen, Y. T. [1 ,2 ]
Huang, S. C. [3 ]
Chen, T. C. [4 ]
Chiang, P. H. [1 ,2 ]
Lin, S. S. [1 ,2 ]
Cheng, Y. T. [1 ,2 ]
机构
[1] Kaohsiung Chang Gung Mem Hosp, Dept Urol, 123 Ta Pei Rd, Kaohsiung 833, Taiwan
[2] Chang Gung Univ, Coll Med, 123 Ta Pei Rd, Kaohsiung, Taiwan
[3] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Anat Pathol, Kaohsiung, Taiwan
[4] Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Div Nephrol, Kaohsiung, Taiwan
关键词
TAIWAN;
D O I
10.1016/j.transproceed.2017.03.071
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives. Polyomavirus has been reported to be oncogenic due to viral integration into the human genome. A relatively high prevalence of upper urinary tract urothelial carcinoma (UTUC) was noted after kidney transplantation (KT) in Taiwan. However, little was known about the impact of polyomavirus on the urothelial cancer behavior. Therefore, the aim of this study is to analyze the characteristics of polyomavirus-related UTUC after KT. Methods. From 2005 to 2014, 27 patients were found to have UTUCs after KT. All the patients underwent standard nephroureterectomy. Detailed perioperative parameters were obtained from chart records. A qualified pathologist who is blinded to the clinical outcome examined large T antigen expression and pathological features. All the patients were divided into two groups according to positive or negative expression of large T antigen. Results. In the patient demography, a significantly younger median age was found in patients with large T antigen-positive UTUCs compared with the negative control group (48.1 +/- 8.3 years versus 54.6 +/- 4.1 years, respectively, P = .013). As for the pathological features and oncologic outcome, there were no obvious differences between these two groups. Non-organ-confined status and positive lymphovascular invasion are prognostic factors associated with systemic disease recurrence (P = .017 and .001, respectively). Conclusions. Although UTUC commonly develops in the elderly, earlier onset of post KT UTUCs was observed especially in patients with positive large T antigen expression in our cohort. This preliminary result provides valuable experience suggesting more frequent upper urinary tract screening for polyomavirus infected patients after KT in Taiwan.
引用
收藏
页码:1064 / 1067
页数:4
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