Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica

被引：332
作者：
Wang, Jing [1 ,2 ]
Zhang, Quanbin [1 ]
Zhang, Zhongshan [1 ,2 ]
Song, Houfang [1 ,2 ]
Li, Pengcheng [1 ]
机构：
[1] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2010年 / 46卷 / 01期
关键词：
Low molecular weight fucoidan; Laminaria japonica; Antioxidant; Anticoagulant; RADICAL SCAVENGING ACTIVITY; OXIDATIVE STRESS; CHROMATOGRAPHY; HEPARIN; OXYGEN; TEA; ROS; XA;
D O I：
10.1016/j.ijbiomac.2009.10.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A low molecular weight fucoidan (DFPS), obtained from the brown seaweed Laminaria japonica, was separated into three fractions by anion-exchange column chromatography. All three fractions (DF1, DF2, DF3) predominantly contained variety fucose, galactose and sulfate group. The antioxidant and anticoagulant activities of these fractions were investigated. The results showed that all fractions possessed considerable antioxidant activities, DF1 was most active. All samples inhibited coagulant in APTT, TT and PT assays obviously. Available data presented the content of sulfate group, the molar ratio of sulfate/fucose and sulfate/total sugar, and the molecular weight played an important role on antioxidant and anticoagulant activity. (C) 2009 Elsevier B.V. All rights reserved.
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收藏
页码：6 / 12
页数：7
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