Pathogenicity of H5N8 highly pathogenic avian influenza viruses isolated from a wild bird fecal specimen and a chicken in Japan in 2014

被引：26
作者：
Tanikawa, Taichiro [1 ]
Kanehira, Katsushi [1 ]
Tsunekuni, Ryota [1 ]
Uchida, Yuko [1 ]
Takemae, Nobuhiro [1 ]
Saito, Takehiko [1 ,2 ]
机构：
[1] Natl Agr & Food Res Org NARO, Natl Inst Anim Hlth, Influenza & Prion Dis Res Ctr, 3-1-5 Kannondai, Tsukuba, Ibaraki 3050856, Japan
[2] Gifu Univ, United Grad Sch Vet Sci, 1-1 Yanagido, Gifu 5011193, Japan
来源：
MICROBIOLOGY AND IMMUNOLOGY | 2016年 / 60卷 / 04期
关键词：
animal RNA virus; H5N8 subtype highly pathogenic avian influenza; chicken; wild bird; pathogenicity; GENETIC-CHARACTERIZATION; VACCINATED CHICKENS; GENOME SEQUENCE; A(H5N8) VIRUS; A H5N2; POULTRY; OUTBREAKS; KOREA; DISSEMINATION; EVOLUTION;
D O I：
10.1111/1348-0421.12369
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Poultry outbreaks caused by H5N8 highly pathogenic avian influenza viruses (HPAIVs) occurred in Japan between December 2014 and January 2015. During the same period; H5N8 HPAIVs were isolated from wild birds and the environment in Japan. The hemagglutinin (HA) genes of these isolates were found to belong to clade 2.3.4.4 and three sub-groups were distinguishable within this clade. All of the Japanese isolates from poultry outbreaks belonged to the same sub-group; whereas wild bird isolates belonged to the other sub-groups. To examine whether the difference in pathogenicity to chickens between isolates of different HA sub-groups of clade 2.3.4.4 could explain why the Japanese poultry outbreaks were only caused by a particular sub-group; pathogenicities of A/chicken/Miyazaki/7/2014 (Miyazaki2014; sub-group C) and A/duck/Chiba/26-372-48/2014 (Chiba2014; sub-group A) to chickens were compared and it was found that the lethality of Miyazaki2014 in chickens was lower than that of Chiba2014; according to the 50% chicken lethal dose. This indicated that differences in pathogenicity may not explain why the Japanese poultry outbreaks only involved group C isolates.
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页码：243 / 252
页数：10
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