MNAzymes provide a universal mechanism for triggering DNAzyme synthesis cascades

被引：8

作者：

Bone, Simon M. ^{[1
,2
]}

Todd, Alison V. ^{[1
,2
]}

机构：

[1] SpeeDx Pty Ltd, Eveleigh, NSW 2015, Australia

[2] Univ New S Wales, Kensington, NSW 2052, Australia

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 87期

关键词：

ROLLING CIRCLE AMPLIFICATION; SIGNAL AMPLIFICATION; DNA DETECTION;

D O I：

10.1039/c4cc05919k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel methods were developed to isothermally detect target nucleic acids and initiate signal amplification cascades. The methods utilize target-specific MNAzymes to activate universal primer molecules. These primers can subsequently promote the autonomous synthesis of DNA-zymes capable of cleaving nucleic acid substrates and generating signal, which further creates the potential for circular feedback.

引用

页码：13243 / 13246

页数：4

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